SCHEMBL203013

SCHEMBL203013

C=C(C)C(=O)Nc1ccc(Oc2ccccc2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.63
SMN1; SMN2 Q16637 1/20 0.63
ALDH1A1 P00352 4/20 0.60
TGM2 P21980 1/20 0.59
EPHX1 P07099 1/20 0.59
PGR P06401 1/20 0.58
NPC1 O15118 1/20 0.56
CRHBP P24387 1/20 0.56
RAB9A P51151 1/20 0.56
CRHR2 Q13324 1/20 0.56
RNF4 P78317 1/20 0.55
RXFP1 Q9HBX9 1/20 0.54
MAPT P10636 2/20 0.53
PNLIP P16233 1/20 0.53
FAAH O00519 1/20 0.52
PDK1 Q15118 1/20 0.52
PDK2 Q15119 1/20 0.52
PDK3 Q15120 1/20 0.52
PDK4 Q16654 1/20 0.52
MEN1 O00255 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3194415 0.87 RXFP1 (0.54) HPGDSMN1; SMN2ALDH1A1RXFP1MAPT
SCHEMBL23966424 0.87 RXFP1 (0.54) HPGDSMN1; SMN2ALDH1A1TGM2NPC1
SCHEMBL21392904 0.85 ALDH1A1 (0.55) HPGDSMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL219147 0.84 KDM4E (0.66) HPGDSMN1; SMN2ALDH1A1TGM2EPHX1
SCHEMBL7603741 0.83 PKM (0.50) SMN1; SMN2ALDH1A1RXFP1MAPTHTT
SCHEMBL3199696 0.83 RXFP1 (0.50) HPGDSMN1; SMN2ALDH1A1TGM2EPHX1
SCHEMBL171438 0.82 HPGD (0.71) HPGDSMN1; SMN2ALDH1A1TGM2EPHX1
SCHEMBL19263968 0.82 HPGD (0.61) HPGDSMN1; SMN2ALDH1A1TGM2EPHX1
SCHEMBL8006359 0.82 HPGD (0.66) HPGDSMN1; SMN2ALDH1A1TGM2EPHX1
SCHEMBL7598040 0.82 MTNR1B (0.51) PGRHTTMTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111072119-B Cationic lignin-based flocculant and preparation method and application thereof 大连工业大学 2020-09-11 CN claimed
CN-111072119-A Cationic lignin-based flocculant and preparation method and application thereof 大连工业大学 2020-04-28 CN claimed
CN-111072119-B Cationic lignin-based flocculant and preparation method and application thereof 大连工业大学 2020-09-11 CN disclosed
CN-111072119-A Cationic lignin-based flocculant and preparation method and application thereof 大连工业大学 2020-04-28 CN disclosed
CN-104803916-B Hete rocyclic derivatives as SARM (SARMS) 詹森药业有限公司 2017-08-11 CN disclosed
CN-104803916-A Novel heterocycle derivatives useful as selective androgen receptor modulators (sarms) JANSSEN PHARMACEUTICA NV 2015-07-29 CN disclosed
EP-1817292-B1 NOVEL HETEROCYCLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) JANSSEN PHARMACEUTICA NV (BE) 2015-04-08 EP disclosed
EP-1817292-B1 NOVEL HETEROCYCLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) JANSSEN PHARMACEUTICA NV (BE) 2015-04-08 EP disclosed
US-8088811-B2 Heterocycle derivatives useful as selective androgen receptor modulators (SARMs) JANSSEN PHARMACEUTICA N.V. (BE) 2012-01-03 US disclosed
US-8088811-B2 Heterocycle derivatives useful as selective androgen receptor modulators (SARMs) JANSSEN PHARMACEUTICA N.V. (BE) 2012-01-03 US disclosed
US-8088811-B2 Heterocycle derivatives useful as selective androgen receptor modulators (SARMs) JANSSEN PHARMACEUTICA N.V. (BE) 2012-01-03 US disclosed
US-7781473-B2 Heterocycle derivatives useful as selective androgen receptor modulators (SARMS) J & J Pharmaceutical Research & Development, LLC. (US) 2010-08-24 US disclosed
US-7781473-B2 Heterocycle derivatives useful as selective androgen receptor modulators (SARMS) J & J Pharmaceutical Research & Development, LLC. (US) 2010-08-24 US disclosed
US-20090131365-A1 NOVEL HETEROCYCLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) ZHANG XUQING 2009-05-21 US disclosed
US-20090131365-A1 NOVEL HETEROCYCLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) ZHANG XUQING 2009-05-21 US disclosed
US-20090131365-A1 NOVEL HETEROCYCLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) ZHANG XUQING 2009-05-21 US disclosed
US-7465809-B2 Heterocycle derivatives useful as selective androgen receptor modulators (SARMs) JANSSEN PHARMACEUTICA N.V. (BG) 2008-12-16 US disclosed
EP-1817292-A2 NOVEL HETEROCYCLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) JANSSEN PHARMACEUTICA N.V. (BE) 2007-08-15 EP disclosed
US-20060211756-A1 Novel heterocycle derivatives useful as selective androgen receptor modulators (SARMs) JANSSEN PHARMACEUTICA N.V. (BE) 2006-09-21 US disclosed
WO-2006055184-A2 NOVEL HETEROCYCLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) JANSSEN PHARMACEUTICA N.V. (BE) 2006-05-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060211756-A1 Novel heterocycle derivatives useful as selective androgen receptor modulators (SARMs) AR, NR5A1, NR5A2 HPGD 705/4885SMN1; SMN2 4074/4885ALDH1A1 1240/4885
US-20090131365-A1 NOVEL HETEROCYCLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AR, NR5A1, NR5A2 HPGD 705/4885SMN1; SMN2 4074/4885ALDH1A1 1240/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.