Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.52 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | CYP51A1 | Q16850 | 6/20 | 0.42 |
| ▸ | PYGL | P06737 | 2/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057132 | 0.87 | TRPV4 (0.49) | TRPV4TAS1R3TAS1R1CYP51A1PYGL | |
| SCHEMBL8004162 | 0.83 | MEN1 (0.36) | TRPV4TAS1R3TAS1R1CYP51A1PYGL | |
| SCHEMBL4056496 | 0.79 | TAS1R3 (0.46) | TRPV4TAS1R3TAS1R1CYP51A1PYGL | |
| SCHEMBL4056099 | 0.79 | TAS1R3 (0.44) | TRPV4TAS1R3TAS1R1CTSSCTSL | |
| SCHEMBL8008195 | 0.79 | TRPV4 (0.43) | TRPV4TAS1R3TAS1R1CYP51A1PYGL | |
| SCHEMBL4972317 | 0.75 | TRPV4 (0.68) | TRPV4TAS1R3TAS1R1CTSSUTS2R | |
| SCHEMBL8010445 | 0.75 | TRPV4 (0.68) | TRPV4TAS1R3TAS1R1CTSSUTS2R | |
| SCHEMBL5004275 | 0.75 | TRPV4 (0.87) | TRPV4TAS1R3TAS1R1CTSSUTS2R | |
| SCHEMBL7995086 | 0.75 | TAS1R3 (0.41) | TRPV4TAS1R3TAS1R1CTSSCTSL | |
| SCHEMBL4972801 | 0.73 | TRPV4 (0.69) | TRPV4TAS1R3TAS1R1CTSSUTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |