Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 3/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.40 |
| ▸ | IDH1 | O75874 | 3/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | IL6ST | P40189 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8674159 | 1.00 | NAAA (0.43) | NAAAFAAHALDH1A1PPARAIDH1 | |
| SCHEMBL6454677 | 0.90 | NAAA (0.46) | NAAAFAAHALDH1A1PPARAIDH1 | |
| SCHEMBL5022256 | 0.90 | NAAA (0.46) | NAAAFAAHALDH1A1PPARAIDH1 | |
| SCHEMBL6442419 | 0.89 | ALDH1A1 (0.46) | NAAAFAAHALDH1A1PPARAIDH1 | |
| SCHEMBL5558778 | 0.89 | ALDH1A1 (0.46) | NAAAFAAHALDH1A1PPARAIDH1 | |
| SCHEMBL27009026 | 0.88 | FAAH (0.49) | NAAAFAAHALDH1A1PPARAIDH1 | |
| SCHEMBL27009889 | 0.88 | FAAH (0.49) | NAAAFAAHALDH1A1PPARAIDH1 | |
| SCHEMBL1750169 | 0.88 | ALDH1A1 (0.55) | NAAAFAAHALDH1A1PPARAIDH1 | |
| SCHEMBL1750168 | 0.88 | ALDH1A1 (0.55) | NAAAFAAHALDH1A1PPARAIDH1 | |
| SCHEMBL19231325 | 0.87 | ALDH1A1 (0.47) | NAAAFAAHALDH1A1PPARAIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166049-A | Use of an antagonist of PPARα and PPARγ for the treatment of syndrome X | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-12-26 | — | — | US | disclosed |
| EP-0772605-A1 | BENZOXAZOLES AND PYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF THE TYPE II DIABETES | SMITHKLINE BEECHAM PLC (GB) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996004260-A1 | BENZOXAZOLES AND PYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF THE TYPE II DIABETES | SMITHKLINE BEECHAM PLC (GB) | 1996-02-15 | — | — | WO | disclosed |