Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GLS | O94925 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8007765 | 0.99 | POLB (0.38) | POLBHSD11B1GRIN1GRIN2BKDM4E | |
| SCHEMBL8008284 | 0.99 | POLB (0.38) | POLBHSD11B1GRIN1GRIN2BKDM4E | |
| SCHEMBL8010417 | 0.98 | POLB (0.41) | POLBHSD11B1GRIN1GRIN2BKMT2A | |
| SCHEMBL8013957 | 0.87 | GRIN1 (0.36) | POLBHSD11B1GRIN1GRIN2B | |
| SCHEMBL8007717 | 0.82 | HDAC6 (0.33) | GRIN1GRIN2B | |
| SCHEMBL7998525 | 0.81 | HDAC1 (0.33) | POLBGRIN1GRIN2BKDM4E | |
| SCHEMBL7999089 | 0.78 | HDAC1 (0.34) | GRIN1GRIN2BKDM4E | |
| SCHEMBL10260440 | 0.76 | ATM (0.36) | POLBKDM4EKMT2ARAB9ANPC1 | |
| SCHEMBL8007763 | 0.75 | GRIN1 (0.35) | GRIN1GRIN2BKDM4ERAB9ANPC1 | |
| SCHEMBL10261621 | 0.75 | ATM (0.36) | POLBKDM4EKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134987-A1 | DIFLUOROMETHYL-CONTAINING MACROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2009-11-05 | — | — | WO | disclosed |