Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 15/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458911 | 0.91 | MPO (0.47) | GPR84KMT2ACYP1A2MEN1ATM | |
| SCHEMBL9531584 | 0.87 | GPR84 (0.50) | GPR84KMT2ACA12CA1CA2 | |
| SCHEMBL17395411 | 0.87 | GPR84 (0.44) | GPR84KMT2ACYP1A2L3MBTL1CA12 | |
| SCHEMBL2585300 | 0.83 | CYP1A2 (0.42) | GPR84KMT2ACYP1A2MEN1L3MBTL1 | |
| SCHEMBL3676992 | 0.83 | GPR84 (0.55) | GPR84KMT2A | |
| SCHEMBL8885004 | 0.81 | GPR84 (0.54) | GPR84KMT2A | |
| SCHEMBL17395402 | 0.80 | GPR84 (0.39) | GPR84KMT2ACYP1A2MEN1CA12 | |
| SCHEMBL9412780 | 0.80 | MAPT (0.51) | KMT2ACYP1A2MEN1L3MBTL1CA12 | |
| SCHEMBL8884936 | 0.79 | GPR84 (0.50) | GPR84KMT2AL3MBTL1 | |
| SCHEMBL14967358 | 0.78 | GPR84 (0.58) | GPR84CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5596006-A | ANTIHYPERTENSIVE, ANTIATHEROSCLEROTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-01-21 | — | — | US | claimed |
| EP-0594019-B1 | 1-Biphenylmethyl-pyridone derivatives, their preparation and their use as angiotensin II antagonistes | BAYER AG (DE) | 2000-02-23 | — | — | EP | disclosed |
| US-5863930-A | ATHEROSCLEROSIS TREATMENT FORMED BY REACTION OF PYRIDONES WITH BIPHENYLMETHYL HALOGEN | BAYER AKTIENGESELLSCHAFT (DE) | 1999-01-26 | — | — | US | disclosed |
| EP-0624583-B1 | Substituted pyridylmethylpyridone as angiotensine II antagonists | BAYER AG (DE) | 1997-07-23 | — | — | EP | disclosed |
| US-5599823-A | HYPOTENSIVE AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-02-04 | — | — | US | disclosed |
| US-5596006-A | ANTIHYPERTENSIVE, ANTIATHEROSCLEROTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-01-21 | — | — | US | disclosed |
| CN-1102648-A | Substituted mono- and bipyridylmethylpyridenes | BAYER AG (DE) | 1995-05-17 | — | — | CN | disclosed |
| US-5407948-A | For treating hypertension, atherosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1995-04-18 | — | — | US | disclosed |
| EP-0624583-A1 | Substituted mono- and bipyridylmethylpyridone as angiotensine II antagonists | BAYER AG (DE) | 1994-11-17 | — | — | EP | disclosed |
| US-5356911-A | Hypotensive agents | BAYER AKTIENGESELLSCHAFT (DE) | 1994-10-18 | — | — | US | disclosed |
| EP-0594019-A1 | Trisubstituted biphenyl as angiotensin II antagonistes | BAYER AG (DE) | 1994-04-27 | — | — | EP | disclosed |
| US-5254543-A | Hypotensive, anticholesterol agents | BAYER AKTIENGESELLSCHAFT (DE) | 1993-10-19 | — | — | US | disclosed |
| EP-0557843-A2 | Sulfonylbenzyl-substituted pyridones as pharmaceuticals | BAYER AG (DE) | 1993-09-01 | — | — | EP | disclosed |
| EP-0542059-A1 | Substituted biphenylpyridinones as angiotensin II antagonists | BAYER AG (DE) | 1993-05-19 | — | — | EP | disclosed |