Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 12/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966592 | 0.84 | GPR84 (0.67) | GPR84 | |
| SCHEMBL9458911 | 0.81 | MPO (0.47) | GPR84LMNAKDM4EALDH1A1TSHR | |
| SCHEMBL2585300 | 0.80 | CYP1A2 (0.42) | GPR84HPGDLMNAKDM4EALDH1A1 | |
| SCHEMBL8007752 | 0.78 | GPR84 (0.52) | GPR84CA1CA2 | |
| SCHEMBL17395411 | 0.77 | GPR84 (0.44) | GPR84LMNAKDM4ECYP4F2CYP4A11 | |
| SCHEMBL9412780 | 0.76 | MAPT (0.51) | HPGDLMNAKDM4EALDH1A1TSHR | |
| SCHEMBL11858938 | 0.76 | GPR84 (0.68) | GPR84 | |
| SCHEMBL8884936 | 0.76 | GPR84 (0.50) | GPR84MMP2HPGDLMNAALDH1A1 | |
| SCHEMBL1928912 | 0.75 | TSHR (0.67) | HPGDLMNAALDH1A1MGLLTSHR | |
| SCHEMBL1926802 | 0.74 | CYP4F2 (0.76) | HPGDLMNAKDM4EALDH1A1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780014-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2014-09-24 | — | — | EP | disclosed |
| WO-2013075083-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS (US) | 2013-05-23 | — | — | WO | disclosed |