Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8425230 | 1.00 | KDM4E (0.40) | KDM4EALDH1A1MAPK1KAT8CA1 | |
| SCHEMBL6951963 | 0.96 | KDM4E (0.43) | KDM4EALDH1A1MAPK1KAT8KMT2A | |
| SCHEMBL6951965 | 0.96 | KDM4E (0.43) | KDM4EALDH1A1MAPK1KAT8KMT2A | |
| SCHEMBL8015719 | 0.91 | KMT2A (0.41) | ALDH1A1KAT8CA1CA2CA9 | |
| SCHEMBL8015723 | 0.91 | KMT2A (0.41) | ALDH1A1KAT8CA1CA2CA9 | |
| SCHEMBL8423675 | 0.87 | PTGS2 (0.42) | KDM4EALDH1A1MAPK1KMT2AGAA | |
| SCHEMBL8022346 | 0.87 | PTGS2 (0.42) | KDM4EALDH1A1MAPK1KMT2AGAA | |
| SCHEMBL6945936 | 0.86 | KMT2A (0.43) | ALDH1A1KAT8CA1CA2CA9 | |
| SCHEMBL6945950 | 0.86 | KMT2A (0.43) | ALDH1A1KAT8CA1CA2CA9 | |
| SCHEMBL8026222 | 0.85 | LMNA (0.45) | ALDH1A1MAPK1KAT8KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | disclosed |
| US-5869516-A | 4-(arylaminomethylene)-2,4-dihydro-3-pyrazolones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-02-09 | — | — | US | disclosed |