Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8009327 | 1.00 | MAPT (0.37) | MAPTTP53ALDH1A1PKMKMT2A | |
| SCHEMBL6952092 | 0.90 | MAPT (0.39) | MAPTTP53ALDH1A1PKMKMT2A | |
| SCHEMBL6952098 | 0.90 | MAPT (0.39) | MAPTTP53ALDH1A1PKMKMT2A | |
| SCHEMBL8008685 | 0.89 | THRB (0.43) | MAPTALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL8008686 | 0.89 | THRB (0.43) | MAPTALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL8008601 | 0.86 | KMT2A (0.34) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL8008599 | 0.86 | KMT2A (0.34) | MAPTALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL8009348 | 0.86 | MAPT (0.48) | MAPTALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL8009336 | 0.86 | MAPT (0.48) | MAPTALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL8009339 | 0.86 | MAPT (0.48) | MAPTALDH1A1PKMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | claimed |
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | disclosed |