SCHEMBL8009628

SCHEMBL8009628

[CH2]c1ccc(N(C(=O)CCCc2ccccc2)C(=O)Cc2ccccc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 8/20 0.52
HDAC1 Q13547 4/20 0.46
HDAC3 O15379 3/20 0.46
HDAC2 Q92769 3/20 0.46
HDAC8 Q9BY41 3/20 0.46
HDAC6 Q9UBN7 3/20 0.46
HDAC5 Q9UQL6 3/20 0.46
HDAC4 P56524 2/20 0.46
HDAC7 Q8WUI4 2/20 0.46
HDAC10 Q969S8 2/20 0.46
HDAC11 Q96DB2 2/20 0.46
HDAC9 Q9UKV0 2/20 0.46
MAPK1 P28482 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
ADRA1A P35348 1/20 0.46
SLC6A3 Q01959 1/20 0.46
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
CASP3 P42574 1/20 0.43
SENP8 Q96LD8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8012661 0.88 CES1 (0.45) ALOX5HDAC8HDAC6REN
SCHEMBL8001072 0.84 TP53 (0.45) ALOX5NPC1RAB9AALDH1A1REN
SCHEMBL8012938 0.83 ALOX5 (0.52) ALOX5HDAC1HDAC3HDAC2HDAC8
SCHEMBL8016514 0.81 ALOX5 (0.53) ALOX5HDAC1HDAC3HDAC2HDAC8
SCHEMBL8012648 0.80 CRHBP (0.43) ALOX5NPC1RAB9AREN
SCHEMBL8013230 0.79 ALOX5 (0.57) ALOX5HDAC1HDAC3HDAC2HDAC8
SCHEMBL8013112 0.78 REN (0.43) ALOX5HDAC1HDAC3HDAC2HDAC8
SCHEMBL8010609 0.75 ALOX5 (0.60) ALOX5HDAC1HDAC2MAPK1SMN1; SMN2
SCHEMBL8012430 0.74 NPSR1 (0.50) SMN1; SMN2NPC1RAB9AALDH1A1REN
SCHEMBL21085193 0.74 FNTA (0.58) ALOX5MAPK1ALDH1A1REN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6117893-A Heterocyclic compounds having anti-diabetic activity and their use SANKYO COMPANY, LIMITED (JP) 2000-09-12 US disclosed
EP-1022274-A1 Oxazolidinedione and Thiazolidinedione derivatves, their preparation and their use Sankyo Company Limited (JP) 2000-07-26 EP disclosed
US-5977365-A HYPOGLYCEMIC AGENTS SANKYO COMPANY, LIMITED (JP) 1999-11-02 US disclosed
US-5624935-A ANTIDIABETIC AGENTS, HYPOGLYCEMIC AGENTS OR ANTILIPEMIC AGENTS SANKYO COMPANY, LIMITED 1997-04-29 US disclosed
EP-0676398-A2 Heterocyclic compounds having anti-diabetic activity, their preparation and their use SANKYO COMPANY LIMITED (JP) 1995-10-11 EP disclosed