Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.67 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.67 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4321538 | 0.83 | HRH3 (0.68) | HRH3HRH4TAAR1SMN1; SMN2 | |
| Immethridine SCHEMBL29462340 | 0.80 | HRH3 (1.00) | HRH3HRH4TAAR1CYP3A4MAPT | |
| Immethridine SCHEMBL30053193 | 0.78 | CYP3A4 (1.00) | HRH3HRH4TAAR1CYP3A4MAPT | |
| SCHEMBL28759658 | 0.77 | HRH3 (1.00) | HRH3HRH4TAAR1CYP3A4MAPT | |
| SCHEMBL7924408 | 0.77 | HRH3 (1.00) | HRH3HRH4TAAR1CYP3A4MAPT | |
| SCHEMBL9783259 | 0.68 | HRH3 (0.73) | HRH3HRH4TAAR1CYP3A4MAPT | |
| SCHEMBL320687 | 0.68 | CALM1 (0.44) | CYP3A4SMN1; SMN2 | |
| SCHEMBL9203875 | 0.68 | MAOA (0.37) | HRH3TAAR1 | |
| SCHEMBL2626810 | 0.68 | HRH3 (0.65) | HRH3HRH4TAAR1CYP3A4MAPT | |
| SCHEMBL10217408 | 0.68 | HRH3 (0.69) | HRH3HRH4TAAR1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043254-A | ANTIPROLIFERATIVE AGENT; ENZYME INHIBITOR | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-28 | — | — | US | claimed |
| WO-1999051590-A1 | SUBSTITUTED INDOLINONES AS KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-14 | — | — | WO | claimed |
| US-6043254-A | ANTIPROLIFERATIVE AGENT; ENZYME INHIBITOR | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-28 | — | — | US | disclosed |
| WO-1999051590-A1 | SUBSTITUTED INDOLINONES AS KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-14 | — | — | WO | disclosed |