Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | NQO2 | P16083 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8005202 | 0.88 | RAB9A (0.37) | MAPTRAB9ANPC1LMNAKDM4E | |
| SCHEMBL8002646 | 0.87 | SLC2A1 (0.36) | MAPTRAB9ANPC1LMNAKDM4E | |
| SCHEMBL8003707 | 0.86 | RAB9A (0.36) | MAPTRAB9ANPC1LMNAKDM4E | |
| SCHEMBL22110048 | 0.79 | ALDH1A1 (0.47) | MAPTLMNAKDM4EMEN1KMT2A | |
| SCHEMBL577146 | 0.77 | MAPT (0.36) | MAPTRAB9ANPC1LMNAKDM4E | |
| SCHEMBL8011476 | 0.77 | MEN1 (0.36) | MAPTRAB9ANPC1LMNAKDM4E | |
| SCHEMBL11951314 | 0.76 | ALDH1A1 (0.37) | MAPTRAB9ANPC1LMNAKDM4E | |
| SCHEMBL1952194 | 0.75 | ALDH1A1 (0.36) | MAPTRAB9ANPC1LMNAKDM4E | |
| SCHEMBL15216113 | 0.75 | KDM4E (0.42) | MAPTLMNAKDM4ENPSR1L3MBTL1 | |
| SCHEMBL15578481 | 0.74 | TYR (0.42) | MAPTRAB9ANPC1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009099596-A2 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARAMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |