Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL972626 | 0.87 | NPSR1 (0.52) | SMN1; SMN2NPSR1GAAATMMAPT | |
| Hydrochloric Acid SCHEMBL2035215 | 0.86 | NPSR1 (0.51) | SMN1; SMN2NPSR1GAAATMMAPT | |
| SCHEMBL8008245 | 0.86 | NPSR1 (0.48) | NPSR1GAAMAPTKDM4EGUCY1B2 | |
| SCHEMBL8009956 | 0.85 | GRN (0.43) | SMN1; SMN2NPSR1GAAACHEMAPT | |
| SCHEMBL8010517 | 0.84 | NPSR1 (0.52) | NPSR1GAAMAPTKDM4EGUCY1B2 | |
| SCHEMBL8009905 | 0.84 | MAPT (0.54) | SMN1; SMN2NPSR1GAAMAPTKDM4E | |
| 3,4,5-Trimethoxybenzamide SCHEMBL8009946 | 0.83 | GRN (0.42) | SMN1; SMN2NPSR1GAAACHEKDM4E | |
| SCHEMBL7999011 | 0.83 | MET (0.51) | NPSR1MAPT | |
| SCHEMBL8013247 | 0.83 | BRD4 (0.51) | SMN1; SMN2NPSR1GAAMAPTKDM4E | |
| SCHEMBL8007265 | 0.82 | KDM4E (0.50) | SMN1; SMN2MAPTKDM4EGUCY1B2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000027394-A1 | ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | UNIVERSITY COLLEGE LONDON (GB) | 2000-05-18 | — | — | WO | disclosed |