SCHEMBL8010261

SCHEMBL8010261

COC=C(C(=O)OC)N(C)c1cccc(C(C#N)=NOC)c1

nearest known ligand 0.33

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HSD17B2 P37059 2/20 0.33
USP30 Q70CQ3 1/20 0.32
HIF1A Q16665 1/20 0.31
NPC1 O15118 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
MAPK1 P28482 1/20 0.31
RAB9A P51151 1/20 0.31
APP P05067 1/20 0.31
HSD17B1 P14061 1/20 0.31
CYP11B1 P15538 1/20 0.30
CYP11B2 P19099 1/20 0.30
ADORA2A P29274 1/20 0.30
ADORA2B P29275 1/20 0.30
ADORA1 P30542 1/20 0.30
PTPN1 P18031 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
IDE P14735 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8500992 0.84 HIF1A (0.42) HSD17B2HIF1ANPC1ALDH1A1MAPT
SCHEMBL8500990 0.84 HIF1A (0.42) HSD17B2HIF1ANPC1ALDH1A1MAPT
SCHEMBL8023055 0.83 HSD17B2 (0.34) HSD17B2USP30HIF1ANPC1ALDH1A1
SCHEMBL8020316 0.80 L3MBTL1 (0.42) HSD17B2NPC1ALDH1A1MAPTMAPK1
SCHEMBL8020311 0.80 L3MBTL1 (0.42) HSD17B2NPC1ALDH1A1MAPTMAPK1
SCHEMBL8020917 0.78 MAPT (0.37) HSD17B2HIF1ANPC1ALDH1A1MAPT
SCHEMBL8022508 0.78 MAPT (0.37) HSD17B2HIF1ANPC1ALDH1A1MAPT
SCHEMBL8020173 0.77 GRM5 (0.36) HSD17B2USP30NPC1ALDH1A1MAPT
SCHEMBL8023961 0.75 MTNR1A (0.34) HIF1ANPC1ALDH1A1MAPTRAB9A
SCHEMBL8500995 0.75 HIF1A (0.43) HSD17B2HIF1ANPC1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0975587-A1 OXIME ETHER COMPOUNDS, THEIR USE AND INTERMEDIATES FOR PREPARATIONS OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-02-02 EP disclosed
WO-1998043949-A1 OXIME ETHER COMPOUNDS, THEIR USE AND INTERMEDIATES FOR PREPARATIONS OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-10-08 WO disclosed