SCHEMBL8500992

SCHEMBL8500992

COC=C(C(=O)OC)N(C)c1cccc(C(C)=NOC)c1

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 1/20 0.42
MAPT P10636 3/20 0.36
ALDH1A1 P00352 2/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
HSD17B2 P37059 2/20 0.35
HSD17B1 P14061 1/20 0.33
RXFP1 Q9HBX9 1/20 0.32
KDM4E B2RXH2 1/20 0.32
PTPN1 P18031 1/20 0.32
HTR1A P08908 1/20 0.32
ADORA3 P0DMS8 1/20 0.32
CCKAR P32238 1/20 0.32
HTR5A P47898 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8500990 1.00 HIF1A (0.42) HIF1AMAPTALDH1A1NPC1RAB9A
SCHEMBL8500995 0.90 HIF1A (0.43) HIF1AMAPTALDH1A1NPC1RAB9A
SCHEMBL8022508 0.89 MAPT (0.37) HIF1AMAPTALDH1A1NPC1RAB9A
SCHEMBL8020917 0.89 MAPT (0.37) HIF1AMAPTALDH1A1NPC1RAB9A
SCHEMBL8020316 0.86 L3MBTL1 (0.42) MAPTALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL8020311 0.86 L3MBTL1 (0.42) MAPTALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL8020434 0.85 PPARG (0.47) HIF1ANPC1RAB9ASMN1; SMN2
SCHEMBL8010261 0.84 HSD17B2 (0.33) HIF1AMAPTALDH1A1NPC1RAB9A
SCHEMBL8020919 0.79 MAPT (0.38) HIF1AMAPTALDH1A1NPC1RAB9A
SCHEMBL8022288 0.78 HIF1A (0.36) HIF1AMAPTALDH1A1NPC1HSD17B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-11286472-A None JP disclosed
JP-H11286472-A OXIME ETHER COMPOUND, USE THEREOF AND ITS PRODUCTION INTERMEDIATE SUMITOMO CHEM CO LTD 1999-10-19 JP disclosed