Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.54 |
| ▸ | DRD3 | P35462 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8013519 | 0.81 | HTR1A (0.53) | HTR1AADRA1A | |
| SCHEMBL2882258 | 0.80 | HTR1A (0.55) | HTR1A | |
| SCHEMBL14198662 | 0.80 | HTR1A (0.55) | HTR1A | |
| SCHEMBL2882249 | 0.80 | HTR1A (0.55) | HTR1A | |
| SCHEMBL976063 | 0.79 | ADRA1A (0.73) | HTR1ADRD2ADRA1ADRD3 | |
| SCHEMBL4616926 | 0.78 | ADRA1A (0.62) | HTR1ADRD2ADRA1ADRD3 | |
| SCHEMBL6032323 | 0.77 | HTR1A (0.53) | HTR1ADRD2 | |
| SCHEMBL978209 | 0.76 | DRD2 (0.58) | HTR1ADRD2ADRA1ADRD3 | |
| SCHEMBL27614423 | 0.76 | HTR1A (0.53) | HTR1AADRA1A | |
| SCHEMBL74384 | 0.75 | ADRA1A (0.85) | HTR1ADRD2ADRA1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127357-A | N-((phenyl, benzodioxinyl or N-heteroarylpiperazinyl)alkyl)-N-(N-heteroaryl)substituted carboxamides | JOHN WYETH & BROTHER, LTD. (GB) | 2000-10-03 | — | — | US | disclosed |
| EP-0512755-B1 | Piperazine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1994-12-14 | — | — | EP | disclosed |
| EP-0512755-A2 | Piperazine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |