Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 3/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.38 |
| ▸ | METAP2 | P50579 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | COMT | P21964 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31339117 | 0.80 | IDO1 (0.59) | IDO1CYP1A2GRM5XDHCTSS | |
| SCHEMBL27822419 | 0.80 | IDO1 (0.41) | ASIC3IDO1HAO1CYP1A1CYP1B1 | |
| SCHEMBL98912 | 0.80 | IDO1 (0.59) | IDO1CYP1A2GRM5XDHCTSS | |
| SCHEMBL5468496 | 0.78 | IDO1 (0.37) | IDO1CYP1A1CYP1A2CYP1B1METAP2 | |
| SCHEMBL3401179 | 0.78 | IDO1 (0.56) | IDO1METAP2XDH | |
| SCHEMBL654803 | 0.74 | METAP2 (0.56) | METAP2 | |
| SCHEMBL1330357 | 0.72 | NUDT1 (0.41) | ASIC3 | |
| SCHEMBL29484275 | 0.72 | GP6 (0.46) | CYP1A2 | |
| SCHEMBL17900086 | 0.72 | GP6 (0.46) | CYP1A2 | |
| SCHEMBL12782331 | 0.71 | MAPT (0.52) | CYP1A1CYP1A2CYP1B1XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297162-B1 | COMPOUNDS | AMURA THERAPEUTICS LTD (GB) | 2012-08-15 | — | — | EP | disclosed |
| WO-2009112839-A1 | COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2009-09-17 | — | — | WO | disclosed |