Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.67 |
| ▸ | GSK3B | P49841 | 3/20 | 0.59 |
| ▸ | BACE1 | P56817 | 3/20 | 0.59 |
| ▸ | THRB | P10828 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.51 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.51 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8010384 | 1.00 | TBXAS1 (0.67) | TBXAS1GSK3BBACE1THRBALDH1A1 | |
| SCHEMBL8020587 | 0.86 | ALDH1A1 (0.74) | TBXAS1THRBALDH1A1KDM4EPKM | |
| SCHEMBL8020581 | 0.86 | ALDH1A1 (0.74) | TBXAS1THRBALDH1A1KDM4EPKM | |
| SCHEMBL9434179 | 0.85 | GSK3B (0.68) | TBXAS1GSK3BBACE1THRBALDH1A1 | |
| SCHEMBL527827 | 0.84 | GSK3B (0.80) | GSK3BBACE1ALDH1A1KDM4EPKM | |
| SCHEMBL527828 | 0.84 | GSK3B (0.80) | GSK3BBACE1ALDH1A1KDM4EPKM | |
| SCHEMBL8740053 | 0.84 | GSK3B (0.80) | GSK3BBACE1ALDH1A1KDM4EPKM | |
| Hydrochloric Acid SCHEMBL7054738 | 0.83 | GSK3B (0.78) | GSK3BBACE1ALDH1A1KDM4EPKM | |
| SCHEMBL10658479 | 0.81 | TBXAS1 (1.00) | TBXAS1LMNA | |
| SCHEMBL11451368 | 0.81 | TBXAS1 (0.79) | TBXAS1THRBALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040309-A | ACTIVE MATERIAL TREATING OF RESTENOSIS, RENAL FAILURE, PULMONARY HYPERTENSION, BENIGN PROSTATIC HYPERTROPHY, MALE ERECTILE DYSFUNCTION, CONGESTIVE HEART FAILURE, STROKE, ANGINA, ATHEROSCLEROSIS, CEREBRAL AND CARDIAC ISCHAEMIA | PFIZER, INC. (US) | 2000-03-21 | — | — | US | disclosed |
| EP-0921124-A1 | Benzothiophene derivatives useful in therapy | Pfizer Limited (GB) | 1999-06-09 | — | — | EP | disclosed |