Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | PKM | P14618 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | THRB | P10828 | 2/20 | 0.71 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.56 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.55 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.55 |
| ▸ | GPR132 | Q9UNW8 | 9/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCND1 | P24385 | 1/20 | 0.51 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.51 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8020581 | 1.00 | ALDH1A1 (0.74) | ALDH1A1KDM4EPKMSMN1; SMN2LMNA | |
| SCHEMBL9434664 | 0.86 | ALDH1A1 (0.72) | ALDH1A1KDM4EPKMSMN1; SMN2LMNA | |
| SCHEMBL8010387 | 0.86 | TBXAS1 (0.67) | ALDH1A1KDM4EPKMSMN1; SMN2LMNA | |
| SCHEMBL8010384 | 0.86 | TBXAS1 (0.67) | ALDH1A1KDM4EPKMSMN1; SMN2LMNA | |
| SCHEMBL2136926 | 0.86 | ALDH1A1 (1.00) | ALDH1A1KDM4EPKMSMN1; SMN2LMNA | |
| SCHEMBL2136928 | 0.86 | ALDH1A1 (1.00) | ALDH1A1KDM4EPKMSMN1; SMN2LMNA | |
| SCHEMBL9035635 | 0.82 | MAOA (0.68) | ALDH1A1SMN1; SMN2LMNATHRBGPR132 | |
| SCHEMBL9367470 | 0.79 | ALDH1A1 (0.82) | ALDH1A1KDM4EPKMSMN1; SMN2LMNA | |
| SCHEMBL9367465 | 0.79 | ALDH1A1 (0.82) | ALDH1A1KDM4EPKMSMN1; SMN2LMNA | |
| SCHEMBL28011530 | 0.78 | MAPK1 (0.64) | LMNAGPR132CMKLR2CMKLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040309-A | ACTIVE MATERIAL TREATING OF RESTENOSIS, RENAL FAILURE, PULMONARY HYPERTENSION, BENIGN PROSTATIC HYPERTROPHY, MALE ERECTILE DYSFUNCTION, CONGESTIVE HEART FAILURE, STROKE, ANGINA, ATHEROSCLEROSIS, CEREBRAL AND CARDIAC ISCHAEMIA | PFIZER, INC. (US) | 2000-03-21 | — | — | US | disclosed |
| EP-0921124-A1 | Benzothiophene derivatives useful in therapy | Pfizer Limited (GB) | 1999-06-09 | — | — | EP | disclosed |