Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016624 | 0.84 | GRIN1 (0.55) | KDM4EALDH1A1MAPTGAAKCNH2 | |
| SCHEMBL2017436 | 0.84 | KCNH2 (0.52) | KDM4EALDH1A1MAPTGAAKCNH2 | |
| SCHEMBL2017504 | 0.84 | KCNH2 (0.66) | KDM4EALDH1A1MAPTGAAKCNH2 | |
| SCHEMBL8010801 | 0.77 | DRD2 (0.48) | KDM4EALDH1A1MAPTGAAKMT2A | |
| SCHEMBL2022608 | 0.75 | KCNH2 (0.53) | MAPTGAAKCNH2 | |
| SCHEMBL2015494 | 0.75 | KCNH2 (0.51) | MAPTGAAKCNH2 | |
| SCHEMBL2018259 | 0.75 | KCNH2 (0.64) | KDM4EMAPTGAAKCNH2 | |
| SCHEMBL8012931 | 0.72 | MEN1 (0.55) | KDM4EALDH1A1MAPTGAAKMT2A | |
| SCHEMBL23123753 | 0.71 | HTR1A (0.50) | KDM4EALDH1A1KCNH2HTR1A | |
| SCHEMBL12232768 | 0.71 | ACHE (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137843-A2 | NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | EMORY UNIVERSITY (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009006437-A1 | NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION | EMORY UNIVERSITY (US) | 2009-01-08 | — | — | WO | disclosed |