Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.51 |
| ▸ | CASP3 | P42574 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GLS | O94925 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8008629 | 0.77 | POLB (0.64) | TDP1L3MBTL1POLBMAPTSMN1; SMN2 | |
| SCHEMBL28441280 | 0.76 | ACHE (0.77) | ACHEPOLB | |
| SCHEMBL816698 | 0.76 | MAPK1 (0.57) | CASP3TDP1L3MBTL1MAPK1MAOB | |
| SCHEMBL18730546 | 0.74 | TDP1 (0.61) | ACHECASP3TDP1L3MBTL1POLB | |
| SCHEMBL805142 | 0.74 | OGA (0.70) | ACHECASP3RAB9ASMN1; SMN2GLS | |
| SCHEMBL6043712 | 0.73 | MAPT (0.64) | ACHECASP3TDP1L3MBTL1MAPK1 | |
| SCHEMBL7973833 | 0.72 | OGA (0.68) | ACHECASP3RAB9ASMN1; SMN2GLS | |
| SCHEMBL29724090 | 0.72 | CASP3 (0.86) | CASP3TDP1L3MBTL1MAPK1MAOB | |
| SCHEMBL1142116 | 0.72 | CASP3 (0.86) | CASP3TDP1L3MBTL1MAPK1MAOB | |
| SCHEMBL16087635 | 0.71 | RPS6KA2 (0.56) | ACHECASP3MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6056939-A | Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals | BRACCO IMAGING S.P.A. (IT) | 2000-05-02 | — | — | US | disclosed |
| EP-0048363-B1 | IMIDAZOLE DERIVATIVES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION AND DRUGS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-07-31 | — | — | EP | disclosed |
| US-4511720-A | HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4366160-A | ANALGESICS | HOFFMANN-LA ROCHE INC. (US) | 1982-12-28 | — | — | US | disclosed |
| US-4355033-A | TREATMENT OF HYPERTENSION | HOFFMAN-LA ROCHE INC. (US) | 1982-10-19 | — | — | US | disclosed |
| EP-0002010-B1 | DERIVATIVES OF 2-IMINO-IMIDAZOLIDINE, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND INTERMEDIATES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-07-14 | — | — | EP | disclosed |
| EP-0048363-A2 | Imidazole derivatives, processes and intermediates for their preparation and drugs containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-03-31 | — | — | EP | disclosed |
| US-4244957-A | HYPOTENSIVE AGENTS | HOFFMAN-LA ROCHE INC. (US) | 1981-01-13 | — | — | US | disclosed |
| EP-0002010-A1 | Derivatives of 2-imino-imidazolidine, processes for their preparation, pharmaceutical compositions containing them and intermediates | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1979-05-30 | — | — | EP | disclosed |