Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11627988 | 0.80 | TAAR1 (0.63) | TAAR1SLC6A2SLC6A4SLC6A3MAOA | |
| SCHEMBL2086605 | 0.80 | TAAR1 (0.63) | TAAR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL11436330 | 0.80 | TAAR1 (0.63) | TAAR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL17892071 | 0.80 | TAAR1 (0.63) | TAAR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL17892258 | 0.80 | TAAR1 (0.63) | TAAR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL17892070 | 0.80 | TAAR1 (0.63) | TAAR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL23188100 | 0.79 | ESR1 (0.48) | TAAR1SLC6A2SLC6A3CYP1A2CHRNA7 | |
| SCHEMBL247628 | 0.79 | TAAR1 (1.00) | TAAR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL5351663 | 0.79 | TAAR1 (1.00) | TAAR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL5005843 | 0.79 | TAAR1 (1.00) | TAAR1SLC6A2SLC6A4SLC6A3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529835-B1 | Optical resolution of (+/-)-2-(4-isobutylphenyl) propionic acid | NAGASE & CO LTD (JP) | 1997-01-22 | — | — | EP | claimed |
| JP-61172853-A | — | — | None | — | — | JP | disclosed |
| US-20110230465-A1 | VIRAL POLYMERASE INHIBITORS | BOEHRINGER INGLEHEIM INTERNATIONAL GMBH (DE) | 2011-09-22 | — | — | US | disclosed |
| US-6093830-A | Enantioselective resolution process for arylpropionic acid drugs from the racemic mixture | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2000-07-25 | — | — | US | disclosed |
| US-5969186-A | COMPLEXING WITH AN ALKALI METAL AND POLYCYCLIC AROMATIC HYDROCARBON | NAGASE & COMPANY, LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| EP-0900780-A1 | METHOD FOR RACEMIZATION OF OPTICALLY ACTIVE AMINES | NAGASE & COMPANY, LTD. (JP) | 1999-03-10 | — | — | EP | disclosed |
| US-5852209-A | Process for optically resolving 2-(3-benzoylphenyl) propionic acid | NAGASE & CO., LTD. (JP) | 1998-12-22 | — | — | US | disclosed |
| US-5621140-A | Resolution of ibuprofen | SYNTEX (U.S.A.) INC. (US) | 1997-04-15 | — | — | US | disclosed |
| EP-0529835-B1 | Optical resolution of (+/-)-2-(4-isobutylphenyl) propionic acid | NAGASE & CO LTD (JP) | 1997-01-22 | — | — | EP | disclosed |
| WO-1996019431-A1 | RESOLUTION OF IBUPROFEN USING A N-ALKYL-D-GLUCAMINE | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-27 | — | — | WO | disclosed |
| EP-0703212-A1 | Process for optically resolving 2-(3-benzoylphenyl) propionic acid | NAGASE & COMPANY, LTD. (JP) | 1996-03-27 | — | — | EP | disclosed |
| US-5321154-A | Optical resolution of (±)-2-(4-isobutylphenyl)-propionic acid | NAGASE & COMPANY, LTD. (JP) | 1994-06-14 | — | — | US | disclosed |
| CN-1022482-C | Optical resolution method of (+/-) -cis or (+/-) -trans-dichlorochrysanthemic acid | KURRAY CO LTD (JP) | 1993-10-20 | — | — | CN | disclosed |
| EP-0529835-A2 | Optical resolution of (+/-)-2-(4-isobutylphenyl) propionic acid | NAGASE & COMPANY, LTD. (JP) | 1993-03-03 | — | — | EP | disclosed |
| US-5191112-A | Salt formation, crystallization | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1993-03-02 | — | — | US | disclosed |
| EP-0298480-B1 | PROCESS FOR THE OPTICAL RESOLUTION OF (+)-CIS OR (+)-TRANS-PERMETHRIC ACID | Kuraray Co., Ltd. (JP) | 1992-10-14 | — | — | EP | disclosed |
| CN-1031221-A | (±)-along or the encompasses processes for optical resolution of (±)-anti--dichlor chrysanthemic acid | KURARAY CO (JP) | 1989-02-22 | — | — | CN | disclosed |
| JP-S61172853-A | OPTICAL RESOLUTION OF (+-)-TRANS-CHRYSANTHEMUM-CARBOXILIC ACID | NOHIRA HIROYUKI | 1986-08-04 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230465-A1 | VIRAL POLYMERASE INHIBITORS | POLR2A, POLR2H, POLR2E | TAAR1 3345/4885SLC6A2 4210/4885SLC6A4 4324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.