Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL801325 | 1.00 | CHRNA7 (0.48) | CHRNA7TDP1ACHEALOX5KDM4E | |
| SCHEMBL801000 | 1.00 | CHRNA7 (0.48) | CHRNA7TDP1ACHEALOX5KDM4E | |
| SCHEMBL6839350 | 0.89 | KDM4E (0.46) | TDP1KDM4ELMNAHIF1AADRA2A | |
| SCHEMBL11938483 | 0.86 | CHRNA7 (0.55) | CHRNA7TDP1ACHEALOX5KDM4E | |
| SCHEMBL11938485 | 0.86 | CHRNA7 (0.55) | CHRNA7TDP1ACHEALOX5KDM4E | |
| SCHEMBL3693273 | 0.86 | CHRNA7 (0.55) | CHRNA7TDP1ACHEALOX5KDM4E | |
| SCHEMBL19200934 | 0.85 | CHRNA7 (0.44) | CHRNA7TDP1ACHEALOX5KDM4E | |
| SCHEMBL18811854 | 0.81 | CHRNA7 (0.41) | CHRNA7TDP1ACHEALOX5KDM4E | |
| SCHEMBL9790482 | 0.81 | NOS3 (0.45) | TDP1KDM4ELMNAHIF1AADRA2A | |
| SCHEMBL29861025 | 0.81 | CYP3A4 (0.46) | TDP1KDM4ELMNAHIF1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11708348-B2 | Protease inhibitors for treatment of coronavirus infections | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-07-25 | — | — | US | disclosed |
| EP-3397629-B1 | METALLOENZYME INHIBITOR COMPOUNDS | NQP 1598 LTD (KY) | 2023-04-19 | — | — | EP | disclosed |
| US-20180127418-A1 | HETEROCYCLES USEFUL AS IDO AND TDO INHIBITORS | HANGZHOU INNOGATE PHARMA CO., LTD. (CN) | 2018-05-10 | — | — | US | disclosed |
| EP-2963016-B1 | OXIME ESTER PHOTOINITIATORS | BASF SE (DE) | 2017-10-11 | — | — | EP | disclosed |
| US-20170266326-A1 | COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS | LANTHEUS MEDICAL IMAGING, INC. (US) | 2017-09-21 | — | — | US | disclosed |
| WO-2017093845-A1 | ANTIBODIES AND ANTIBODY FRAGMENTS FOR SITE-SPECIFIC CONJUGATION | PFIZER INC. (US) | 2017-06-08 | — | — | WO | disclosed |
| US-20170154766-A1 | SILICON-CONTAINING CONDENSATE, COMPOSITION FOR FORMING A SILICON-CONTAINING RESIST UNDER LAYER FILM, AND PATTERNING PROCESS | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2017-06-01 | — | — | US | disclosed |
| US-20170145011-A1 | Pyrrolopyrazine-Spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMA (US) | 2017-05-25 | — | — | US | disclosed |
| EP-2804868-B1 | PYRAN-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2017-04-12 | — | — | EP | disclosed |
| US-9550000-B2 | Compositions, methods, and systems for the synthesis and use of imaging agents | LANTHEUS MEDICAL IMAGING, INC. (US) | 2017-01-24 | — | — | US | disclosed |
| EP-0393742-B1 | Process for the preparation of alkyl substituted tetralins and indanes | QUEST INT (NL) | 1994-11-30 | — | — | EP | disclosed |
| US-5292720-A | Formate ester indane compounds | UNION CAMP CORPORATION (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0523697-A1 | Color-developing compositions and their use | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1993-01-20 | — | — | EP | disclosed |
| US-5079386-A | PROCESS FOR THE PREPARATION OF ALKYL SUBSTITUTED TETRALINS AND INDANES | UNILEVER PATENT HOLDINGS B.V. (NL) | 1992-01-07 | — | — | US | disclosed |
| US-5023366-A | Reacted with a benzyl halide, alcohol or ether; for pressure sensitive elements | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1991-06-11 | — | — | US | disclosed |
| EP-0393742-A1 | Process for the preparation of alkyl substituted tetralins and indanes | QUEST INTERNATIONAL B.V. (NL) | 1990-10-24 | — | — | EP | disclosed |
| EP-0268878-A2 | Salicylic acid copolymers and their metal salts, production process thereof, color-developing agents comprising metal salts of the copolymers and color-developing sheets employing the agents | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1988-06-01 | — | — | EP | disclosed |
| US-4352748-A | Novel acyl-polyalkylindan compounds and the use thereof as a base for perfume, as well as perfume compositions | NAARDEN INTERNATIONAL N.V. (NL) | 1982-10-05 | — | — | US | disclosed |
| US-4118424-A | 1,1-BIS/P-ETHOXY-PHENYL/-PROPANE DERIVATIVES | UNIVERSITY OF ILLINOIS FOUNDATION (US) | 1978-10-03 | — | — | US | disclosed |
| US-4003950-A | Diphenyl methane biodegradable insecticides | UNIVERSITY OF ILLINOIS FOUNDATION (US) | 1977-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170145011-A1 | Pyrrolopyrazine-Spirocyclic piperidine amides as modulators of ion channels | KCNJ2, KCNJ5, KCNJ1 | CHRNA7 296/4885TDP1 3809/4885ACHE 1784/4885 |
| US-20180127418-A1 | HETEROCYCLES USEFUL AS IDO AND TDO INHIBITORS | IDO1, IDO2, TDO2 | CHRNA7 2997/4885TDP1 463/4885ACHE 938/4885 |
| US-20170266326-A1 | COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS | FABP3, TNNI3, TNNT2 | CHRNA7 1882/4885TDP1 1114/4885ACHE 105/4885 |
| US-11708348-B2 | Protease inhibitors for treatment of coronavirus infections | ACE, ACE2, TMPRSS2 | CHRNA7 4407/4885TDP1 3714/4885ACHE 289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.