Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | Q9HBH1 | 2/20 | 0.52 | |
| ▸ | TUBB1 | Q9H4B7 | 7/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.45 |
| ▸ | TUBB | P07437 | 6/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.45 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.45 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.45 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.45 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16994940 | 0.90 | PDF (0.49) | PDFTUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL290525 | 0.87 | PDF (0.53) | PDFTUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL299691 | 0.87 | PTGS2 (0.39) | PDFTUBB1SMN1; SMN2MAPT | |
| SCHEMBL290051 | 0.83 | PDF (0.52) | PDFTUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL290356 | 0.82 | PTGS2 (0.61) | PDFTUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL289532 | 0.81 | NPC1 (0.57) | PDFLMNASMN1; SMN2MAPT | |
| SCHEMBL290314 | 0.78 | PDF (0.42) | PDFTUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL290619 | 0.78 | ALDH1A1 (0.43) | PDFTUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL2127784 | 0.78 | TUBB1 (0.50) | PDFTUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL16994939 | 0.77 | PDF (0.50) | PDFTUBB1TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2959898-A1 | 4,5-DIOXO-NAPHTHO[1,2-b]FURANS AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | Sloan-Kettering Institute for Cancer Research (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2427057-B1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | SLOAN KETTERING INST CANCER (US) | 2015-08-12 | — | — | EP | disclosed |
| US-20120071523-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2012-03-22 | — | — | US | disclosed |
| US-20120071523-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2012-03-22 | — | — | US | disclosed |
| WO-2010129049-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071523-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | PDF, EIF5B, EIF4E | PDF 1/4885TUBB1 1432/4885TUBB4A 1484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.