Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.74 |
| ▸ | MMP9 | P14780 | 7/20 | 0.74 |
| ▸ | MMP8 | P22894 | 6/20 | 0.74 |
| ▸ | MMP1 | P03956 | 9/20 | 0.71 |
| ▸ | MMP3 | P08254 | 8/20 | 0.71 |
| ▸ | MMP13 | P45452 | 5/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.50 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.50 |
| ▸ | MMP14 | P50281 | 2/20 | 0.50 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.50 |
| ▸ | ADAM33 | Q9BZ11 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 4/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077830 | 0.89 | MMP2 (0.69) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL8002828 | 0.88 | MMP2 (0.57) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7079905 | 0.81 | MMP2 (0.59) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7074188 | 0.81 | MMP2 (0.52) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7133554 | 0.79 | MMP2 (0.77) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7073432 | 0.77 | MMP2 (0.60) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7074125 | 0.77 | MMP2 (0.65) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7422537 | 0.77 | MMP2 (0.56) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7534733 | 0.76 | MMP2 (0.58) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7077710 | 0.76 | MMP2 (0.70) | MMP2MMP9MMP8MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6118001-A | ANTICANCER AGENT; ANTIARTHRITIC AGENT | DARWIN DISCOVERY, LTD. (GB) | 2000-09-12 | — | — | US | disclosed |