Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.62 |
| ▸ | DRD3 | P35462 | 6/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.62 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 4/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465587 | 1.00 | DRD2 (0.62) | DRD2DRD3ADRA1ALPAR2RECQL | |
| SCHEMBL7465581 | 1.00 | DRD2 (0.62) | DRD2DRD3ADRA1ALPAR2RECQL | |
| SCHEMBL8995901 | 0.83 | DRD2 (0.44) | DRD2DRD3ADRA1ALPAR2 | |
| SCHEMBL8995898 | 0.83 | DRD2 (0.44) | DRD2DRD3ADRA1ALPAR2 | |
| SCHEMBL8013991 | 0.81 | DRD2 (0.57) | DRD2DRD3ADRA1ARECQLHTR1A | |
| SCHEMBL74384 | 0.79 | ADRA1A (0.85) | DRD2DRD3ADRA1AHTR1AADRA1D | |
| SCHEMBL8013988 | 0.78 | DRD2 (0.63) | DRD2DRD3ADRA1ARECQLHTR1A | |
| SCHEMBL5423523 | 0.78 | DRD2 (0.52) | DRD2DRD3ADRA1ALPAR2HTR1A | |
| SCHEMBL5423525 | 0.78 | DRD2 (0.52) | DRD2DRD3ADRA1ALPAR2HTR1A | |
| SCHEMBL12304200 | 0.77 | DRD2 (0.66) | DRD2DRD3ADRA1ARECQLIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127357-A | N-((phenyl, benzodioxinyl or N-heteroarylpiperazinyl)alkyl)-N-(N-heteroaryl)substituted carboxamides | JOHN WYETH & BROTHER, LTD. (GB) | 2000-10-03 | — | — | US | disclosed |
| EP-0512755-B1 | Piperazine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1994-12-14 | — | — | EP | disclosed |
| EP-0512755-A2 | Piperazine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |