SCHEMBL8014285

SCHEMBL8014285

CCC[SiH]1CCC(C2CCC(c3ccc(-c4ccc(Cl)cc4)cc3)CC2)CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 2/20 0.46
LSS P48449 1/20 0.35
SLC2A1 P11166 1/20 0.35
SLC6A3 Q01959 2/20 0.34
HTR3A P46098 1/20 0.33
SRD5A1 P18405 2/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
CCR1 P32246 1/20 0.32
MAPT P10636 2/20 0.32
USP2 O75604 1/20 0.32
LMNA P02545 1/20 0.32
TP53 P04637 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2C9 P11712 1/20 0.32
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
HIF1A Q16665 1/20 0.32
SPHK1 Q9NYA1 1/20 0.31
SLC18A3 Q16572 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8014280 1.00 DRD2 (0.46) DRD2LSSSLC2A1SLC6A3HTR3A
SCHEMBL8038294 0.96 DRD2 (0.49) DRD2LSSSLC2A1SLC6A3HTR3A
SCHEMBL8038298 0.96 DRD2 (0.49) DRD2LSSSLC2A1SLC6A3HTR3A
SCHEMBL8076438 0.87 DRD2 (0.54) DRD2LSSSLC2A1SLC6A3HTR3A
SCHEMBL8076440 0.87 DRD2 (0.54) DRD2LSSSLC2A1SLC6A3HTR3A
SCHEMBL8018213 0.86 DRD2 (0.43) DRD2LSSSLC2A1SLC6A3HTR3A
SCHEMBL8018219 0.86 DRD2 (0.43) DRD2LSSSLC2A1SLC6A3HTR3A
SCHEMBL8018217 0.86 DRD2 (0.43) DRD2LSSSLC2A1SLC6A3HTR3A
SCHEMBL9008539 0.86 DRD2 (0.43) DRD2LSSSLC2A1SLC6A3HTR3A
SCHEMBL8040070 0.86 DRD2 (0.46) DRD2LSSSLC2A1HTR3ASPHK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0670322-B1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHINETSU CHEMICAL CO (JP) 2000-01-19 EP disclosed
US-5582764-A Silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-12-10 US disclosed
EP-0670322-A1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it Shin-Etsu Chemical Co., Ltd. (JP) 1995-09-06 EP disclosed