SCHEMBL8015451

SCHEMBL8015451

O=C(O)c1ccc(NO)c(Cl)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.61
ALDH1A1 P00352 3/20 0.55
MAPT P10636 1/20 0.55
PDK1 Q15118 1/20 0.53
PDK2 Q15119 1/20 0.53
PDK3 Q15120 1/20 0.53
PDK4 Q16654 1/20 0.53
PYGL P06737 3/20 0.51
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
BCL6 P41182 1/20 0.50
BCOR Q6W2J9 1/20 0.50
SRD5A2 P31213 1/20 0.48
TTR P02766 1/20 0.47
KDM4E B2RXH2 2/20 0.47
MRGPRX4 Q96LA9 1/20 0.45
ALOX15 P16050 1/20 0.45
KDM5A P29375 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
EPHX2 P34913 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13808926 0.84 ALDH1A1 (0.70) TSHRALDH1A1MAPTMEN1KMT2A
SCHEMBL7976731 0.82 ALDH1A1 (0.73) TSHRALDH1A1MAPTPDK1PDK2
SCHEMBL988555 0.82 TSHR (0.59) TSHRALDH1A1MAPTPDK1PDK2
Hydrochloric Acid SCHEMBL4728655 0.81 ALDH1A1 (0.71) TSHRALDH1A1MAPTPDK1PDK2
SCHEMBL1105954 0.79 PDK1 (0.60) TSHRALDH1A1MAPTPDK1PDK2
SCHEMBL10470789 0.79 KDM5A (0.67) TSHRALDH1A1MAPTPDK1PDK2
SCHEMBL30780105 0.78 ALDH1A1 (0.66) TSHRALDH1A1MAPTPDK1PDK2
SCHEMBL2617356 0.78 HCAR3 (0.59) TSHRALDH1A1MAPTPDK1PDK2
SCHEMBL29114291 0.78 ALDH1A1 (0.66) TSHRALDH1A1MAPTPDK1PDK2
SCHEMBL8340169 0.78 AKR1C3 (0.53) TSHRALDH1A1MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0453313-B1 Dresser for electromagnetic cookers NIPPON PETROCHEMICALS CO LTD (JP) 2000-01-19 EP disclosed
US-5486683-A Method of cooking using an electromagnetic cooker cover plate NIPPON PETROCHEMICALS COMPANY, LIMITED (JP) 1996-01-23 US disclosed
US-5124397-A Blend of thermotropic liquid crystalline polmer and glassy carbon NIPPON PETROCHEMICALS COMPANY, LIMITED (JP) 1992-06-23 US disclosed
EP-0453313-A2 Dresser for electromagnetic cookers NIPPON PETROCHEMICALS COMPANY, LIMITED (JP) 1991-10-23 EP disclosed