Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | KIF11 | P52732 | 7/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10586768 | 0.77 | DRD3 (0.57) | SIGMAR1EBPDRD2DRD4OPRM1 | |
| SCHEMBL11644799 | 0.76 | KIF11 (0.57) | CCR1SIGMAR1EBPDRD2DRD4 | |
| SCHEMBL13271382 | 0.76 | CYP2D6 (0.44) | CCR1SIGMAR1EBPDRD2DRD4 | |
| SCHEMBL11646224 | 0.75 | SIGMAR1 (0.55) | CCR1SIGMAR1EBPDRD2DRD4 | |
| SCHEMBL11448920 | 0.74 | EBP (0.51) | CCR1SIGMAR1EBPDRD2DRD4 | |
| SCHEMBL11630708 | 0.73 | CCR1 (0.45) | CCR1SIGMAR1EBPDRD2DRD4 | |
| SCHEMBL51900 | 0.73 | EBP (0.59) | CCR1SIGMAR1EBPDRD2DRD4 | |
| SCHEMBL5754187 | 0.73 | CCR1 (0.40) | CCR1SIGMAR1EBPDRD2DRD4 | |
| SCHEMBL20698826 | 0.72 | CCR1 (0.43) | CCR1SIGMAR1EBPALDH1A1 | |
| SCHEMBL7313591 | 0.71 | CCR1 (0.39) | CCR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1014973-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2000-09-20 | — | — | EP | disclosed |
| EP-1014973-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-07-05 | — | — | EP | disclosed |
| US-6057350-A | Alpha 1a adrenergic receptor antagonists | MERCK & CO., INC. (US) | 2000-05-02 | — | — | US | disclosed |
| WO-1998057632-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |