SCHEMBL8016751

SCHEMBL8016751

Clc1ccc(-c2nc3ccccc3nc2-c2ccc(Cl)cc2)cc1

nearest known ligand 0.91

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 6/20 0.91
KDM4E B2RXH2 5/20 0.91
LMNA P02545 3/20 0.91
GAA P10253 1/20 0.91
PKM P14618 1/20 0.59
NPC1 O15118 3/20 0.58
RAB9A P51151 3/20 0.58
TDP1 Q9NUW8 4/20 0.57
MEN1 O00255 2/20 0.57
KMT2A Q03164 2/20 0.57
SMN1; SMN2 Q16637 1/20 0.57
AKT1 P31749 1/20 0.53
AKT2 P31751 1/20 0.53
CDH1 P12830 1/20 0.53
APC P25054 1/20 0.53
CTNNB1 P35222 1/20 0.53
TCF7L2 Q9NQB0 1/20 0.53
MAPK10 P53779 1/20 0.52
MAPK14 Q16539 1/20 0.52
ALDH1A1 P00352 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21942172 0.96 KDM4E (1.00) L3MBTL1KDM4ELMNAGAAPKM
SCHEMBL30934474 0.96 KDM4E (1.00) L3MBTL1KDM4ELMNAGAAPKM
SCHEMBL10562765 0.89 KDM4E (0.77) L3MBTL1KDM4ELMNAGAAPKM
SCHEMBL10688013 0.85 KDM4E (0.68) L3MBTL1KDM4ELMNAGAAPKM
SCHEMBL14416952 0.84 KDM4E (0.79) L3MBTL1KDM4ELMNAGAAPKM
SCHEMBL13950894 0.82 KDM4E (0.78) L3MBTL1KDM4ELMNAGAAPKM
SCHEMBL28202635 0.81 KDM4E (0.69) L3MBTL1KDM4ELMNAGAAPKM
SCHEMBL14211971 0.81 KDM4E (0.75) L3MBTL1KDM4ELMNAGAAPKM
SCHEMBL22989032 0.81 L3MBTL1 (0.73) L3MBTL1KDM4ELMNAGAAPKM
SCHEMBL28281957 0.81 KDM4E (0.62) L3MBTL1KDM4ELMNAGAAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0711803-B1 Method for preventing emission of fluorescence from polyalkylenenaphthalene-2,6-dicarboxylate TEIJIN LTD (JP) 2000-01-19 EP claimed
US-5651926-A SYNERGISTIC SUPPRESSION WITH CYCLIC IMINO ESTERS AND QUINOXALINES TEIJIN LIMITED (JP) 1997-07-29 US claimed
EP-0711803-A2 Method for preventing emission of fluorescence from polyalkylenenaphthalene-2,6-dicarboxylate TEIJIN LIMITED (JP) 1996-05-15 EP claimed
EP-0711803-B1 Method for preventing emission of fluorescence from polyalkylenenaphthalene-2,6-dicarboxylate TEIJIN LTD (JP) 2000-01-19 EP disclosed
US-5651926-A SYNERGISTIC SUPPRESSION WITH CYCLIC IMINO ESTERS AND QUINOXALINES TEIJIN LIMITED (JP) 1997-07-29 US disclosed
EP-0711803-A2 Method for preventing emission of fluorescence from polyalkylenenaphthalene-2,6-dicarboxylate TEIJIN LIMITED (JP) 1996-05-15 EP disclosed