SCHEMBL8017287

SCHEMBL8017287

Cc1cc(O)n(-c2ccccc2)c(=O)c1NC=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.42
CYP3A4 P08684 2/20 0.42
CYP2D6 P10635 2/20 0.42
ALDH1A1 P00352 6/20 0.40
KMT2A Q03164 3/20 0.40
MEN1 O00255 2/20 0.40
RECQL P46063 1/20 0.40
MAPK1 P28482 1/20 0.39
HSD17B10 Q99714 2/20 0.38
CYP1A2 P05177 2/20 0.38
AHR P35869 1/20 0.38
LMNA P02545 2/20 0.37
KDM4E B2RXH2 2/20 0.36
ALOX15 P16050 2/20 0.36
HPGD P15428 2/20 0.36
CYP2C9 P11712 1/20 0.36
PKM P14618 1/20 0.36
CYP2C19 P33261 1/20 0.36
HDAC1 Q13547 2/20 0.36
HDAC2 Q92769 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9790454 0.86 PDE3B (0.34) ALDH1A1KMT2AMEN1MAPK1HSD17B10
SCHEMBL10626056 0.85 ALDH1A1 (0.44) MAPTALDH1A1KMT2AMEN1HSD17B10
SCHEMBL9401741 0.82 CYP2C19 (0.36) MAPTALDH1A1KMT2AMEN1LMNA
SCHEMBL11586370 0.81 MAPT (0.41) MAPTCYP3A4CYP2D6ALDH1A1KMT2A
SCHEMBL11429528 0.78 MAPT (0.49) MAPTCYP3A4CYP2D6ALDH1A1KMT2A
SCHEMBL9401958 0.74 TTR (0.31)
SCHEMBL11429742 0.73 SMN1; SMN2 (0.51) MAPTCYP3A4CYP2D6ALDH1A1KMT2A
SCHEMBL5372425 0.73 LMNA (0.57) MAPTCYP3A4CYP2D6ALDH1A1KMT2A
SCHEMBL11443266 0.72 LMNA (0.45) MAPTCYP3A4CYP2D6ALDH1A1KMT2A
SCHEMBL11310457 0.72 LMNA (0.45) MAPTCYP3A4CYP2D6ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648816-B1 Dyeing of leather with dyestuff mixtures CIBA SC HOLDING AG (CH) 2000-01-26 EP disclosed
EP-0648816-A1 Dyeing of leather with dyestuff mixtures CIBA-GEIGY AG (CH) 1995-04-19 EP disclosed
EP-0061670-B2 Process for dyeing leather and pelts with dye mixtures CIBA GEIGY AG (CH) 1994-06-01 EP disclosed
US-5204453-A Process for the preparation of 1:2 metal complex azo compounds by carrying out diazotization and coupling in the presence of a metal donor CIBA-GEIGY CORPORATION (US) 1993-04-20 US disclosed
US-5128455-A WATER-SOLUBLE FIBER-REACTIVE DYES, CONTAINING AN AMINO-SUBSTITUTED 5-TRIAZINE RING WITH A FIBER-REACTIVE GROUP OF THE VINYLSULFONE SERIES HOECHST AKTIENGESELLSCHAFT (DE) 1992-07-07 US disclosed
EP-0278910-B1 HEAVY METAL COMPLEX DYESTUFFS, THEIR PREPARATION AND THEIR USE CIBA-GEIGY AG (CH) 1992-01-22 EP disclosed
EP-0231147-B1 PROCESS FOR THE TRICHROMATIC DYEING OF LEATHER CIBA-GEIGY AG (CH) 1992-01-15 EP disclosed
EP-0241414-B1 PROCESS FOR THE PREPARATION OF 1:2 METAL COMPLEX AZO DYES CIBA-GEIGY AG (CH) 1991-05-08 EP disclosed
US-5003049-A Fiber-Reactive Dyes for Hydroxy Textiles BASF AKTIENGESELLSCHAFT (DE) 1991-03-26 US disclosed
US-5001227-A Fibre-reactive 1:1 chromium complex azo or azomethine dyes having a bidentate chelating group and a monofunctional neutral ligand CIBA-GEIGY CORPORATION (US) 1991-03-19 US disclosed
US-4340536-A Chrome-complex dyes and the production and use thereof CIBA-GEIGY CORPORATION (US) 1982-07-20 US disclosed
US-4331596-A Arylazoarylazo-substituted azo, azomethine 1:2 chromium complex dyes CIBA-GEIGY CORPORATION (US) 1982-05-25 US disclosed
EP-0009466-B1 1 : 2-BIS-CHROMIUM-COMPLEX DYESTUFFS FROM POLYAZO- OR DISAZO-AZOMETHINE COMPOUNDS, THEIR PREPARATION AND THEIR USE CIBA-GEIGY AG (CH) 1982-05-19 EP disclosed
US-4318849-A COPPER, NICKEL, CHROMIUM OR COBALT COMPLEXES OF AZO OR AZO-METHINE DYES CIBA-GEIGY CORPORATION (US) 1982-03-09 US disclosed
EP-0037377-A1 Metal-complex dyestuffs, their preparation and use CIBA-GEIGY AG (CH) 1981-10-07 EP disclosed
EP-0019851-A1 1:2 Chromium complex dyestuffs of the azomethine and/or azo series, their preparation and use in dyeing and printing polyamide or cellulose materials CIBA-GEIGY AG (CH) 1980-12-10 EP disclosed
US-4215042-A PRINTING AND DYEING OF POLYAMIDES; COLORFASTNESS CIBA-GEIGY CORPORATION (US) 1980-07-29 US disclosed
US-4116952-A POLYAMIDES CIBA-GEIGY CORPORATION (US) 1978-09-26 US disclosed
US-4079052-A Diazopigments containing pyridine derivatives CIBA-GEIGY CORPORATION (US) 1978-03-14 US disclosed
US-4033942-A Chromium complex dye, including azo and azo methine dye compounds CIBA-GEIGY AG (CH) 1977-07-05 US disclosed