Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | TPMT | P51580 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9105728 | 0.81 | NPC1 (0.53) | MTNR1AMTNR1BNPC1RAB9ACYP11B1 | |
| SCHEMBL10983071 | 0.77 | OXER1 (0.47) | HCAR3ALDH1A1 | |
| SCHEMBL7422778 | 0.74 | KDM4E (0.40) | MTNR1AMTNR1BKDM4ECYP11B1CYP11B2 | |
| SCHEMBL29703917 | 0.74 | HDAC6 (0.50) | NPC1RAB9AHCAR3ALDH1A1 | |
| SCHEMBL16413519 | 0.73 | L3MBTL1 (0.56) | MTNR1AMTNR1BKDM4EMCL1ALDH1A1 | |
| SCHEMBL17680280 | 0.72 | MTNR1A (0.46) | MTNR1AMTNR1BNPC1RAB9AKDM4E | |
| SCHEMBL31721264 | 0.70 | KDM4E (0.46) | KDM4EHCAR3MCL1ALDH1A1CA12 | |
| SCHEMBL13290538 | 0.70 | KDM4E (0.46) | KDM4EHCAR3MCL1ALDH1A1 | |
| SCHEMBL28269380 | 0.69 | KDM4E (0.45) | RAB9AKDM4EHCAR3MCL1ALDH1A1 | |
| SCHEMBL28271125 | 0.69 | KDM4E (0.45) | KDM4EHCAR3MCL1ALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |