Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8572351 | 0.87 | SLC18A3 (0.56) | SLC18A3TSHRDRD2DRD3 | |
| SCHEMBL10532482 | 0.81 | DRD2 (0.50) | SLC18A3DRD2HTR1ADRD1DRD5 | |
| SCHEMBL8012789 | 0.80 | DRD2 (0.60) | SLC18A3DRD2HTR1ADRD1DRD5 | |
| SCHEMBL10514525 | 0.80 | SLC18A3 (0.44) | SLC18A3DRD2HTR1ADRD1DRD5 | |
| SCHEMBL27874506 | 0.78 | DRD2 (0.49) | SLC18A3TSHRDRD2HTR1ADRD1 | |
| SCHEMBL8220682 | 0.78 | TSHR (0.60) | SLC18A3TSHRDRD2DRD3 | |
| SCHEMBL8966946 | 0.78 | DRD2 (0.52) | SLC18A3DRD2HTR1ADRD1DRD5 | |
| SCHEMBL10600104 | 0.78 | SLC18A3 (1.00) | SLC18A3DRD2 | |
| SCHEMBL6991321 | 0.77 | DRD2 (0.53) | SLC18A3DRD2HTR1ADRD1DRD5 | |
| SCHEMBL8001944 | 0.77 | DRD2 (0.65) | TSHRDRD2HTR1ADRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090808-A | PSYCHOLOGICAL DISORDERS; ANTICONVULSANTS | H. LUNDBECK A/S (DK) | 2000-07-18 | — | — | US | claimed |
| EP-0649407-B1 | DIMERIC PIPERIDINE, TETRAHYDROPYRIDINE AND PIPERAZINE DERIVATIVES | LUNDBECK & CO AS H (DK) | 1998-08-05 | — | — | EP | claimed |
| US-6090808-A | PSYCHOLOGICAL DISORDERS; ANTICONVULSANTS | H. LUNDBECK A/S (DK) | 2000-07-18 | — | — | US | disclosed |
| US-5658921-A | POTENT SIGMA RECEPTOR LIGANDS; WATER SOLUBILITY; SYMMETRY | H. LUNDBECK A/S (DK) | 1997-08-19 | — | — | US | disclosed |