Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.51 |
| ▸ | SORD | Q00796 | 1/20 | 0.49 |
| ▸ | OGA | O60502 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8012858 | 0.85 | DRD2 (0.63) | TAOK1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8010250 | 0.80 | ALDH1A1 (0.54) | ALDH1A1LMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL8011059 | 0.79 | HRH4 (0.56) | HRH4SORDDRD2DRD4HTR2C | |
| SCHEMBL14427198 | 0.76 | KMT2A (0.68) | TAOK1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8919985 | 0.76 | MEN1 (0.64) | TAOK1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8297534 | 0.76 | MEN1 (0.61) | TAOK1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL978086 | 0.76 | MEN1 (0.61) | ALDH1A1LMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL10245567 | 0.76 | MEN1 (0.60) | TAOK1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8001825 | 0.75 | LMNA (0.60) | ALDH1A1LMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL4714057 | 0.75 | MEN1 (0.66) | TAOK1ALDH1A1LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127357-A | N-((phenyl, benzodioxinyl or N-heteroarylpiperazinyl)alkyl)-N-(N-heteroaryl)substituted carboxamides | JOHN WYETH & BROTHER, LTD. (GB) | 2000-10-03 | — | — | US | disclosed |
| CN-1040106-C | Process for preparing piperazine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1998-10-07 | — | — | CN | disclosed |
| EP-0512755-B1 | Piperazine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1994-12-14 | — | — | EP | disclosed |
| EP-0512755-A2 | Piperazine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1992-11-11 | — | — | EP | disclosed |