SCHEMBL801782

SCHEMBL801782

O=C1C=CC(=O)C(Cl)C1Cl

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
S100A4 P26447 1/20 0.36
HSP90AA1 P07900 1/20 0.36
ALDH1A1 P00352 1/20 0.31
BCHE P06276 1/20 0.31
POLB P06746 1/20 0.31
MAOA P21397 1/20 0.31
ACHE P22303 1/20 0.31
MAOB P27338 1/20 0.31
APEX1 P27695 1/20 0.31
MAPK1 P28482 1/20 0.31
CASP1 P29466 1/20 0.31
RECQL P46063 1/20 0.31
BLM P54132 1/20 0.31
MDM2 Q00987 1/20 0.31
DHODH Q02127 1/20 0.31
HSD17B10 Q99714 1/20 0.31
APOBEC3G Q9HC16 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethane SCHEMBL11661866 0.93 S100A4 (0.33) S100A4HSP90AA1
SCHEMBL17241926 0.78 HSP90AA1 (0.30) HSP90AA1
SCHEMBL9847664 0.77
SCHEMBL8228480 0.65
SCHEMBL12706333 0.61
SCHEMBL12159902 0.61
SCHEMBL13019275 0.61 ALDH1A1 (0.31) HSP90AA1ALDH1A1BCHEPOLBMAOA
SCHEMBL10046205 0.61
SCHEMBL17131854 0.61 ALDH1A1 (0.31) HSP90AA1ALDH1A1BCHEPOLBMAOA
SCHEMBL11355322 0.61

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106146704-B Preparation method of halogenated polymer 中国石油化工股份有限公司 2018-12-28 CN disclosed
CN-106146710-B Cationic polymerization method 中国石油化工股份有限公司 2018-12-28 CN disclosed
CN-106317349-B Styrene-isomonoolefin-styrene triblock copolymer and preparation method thereof 中国石油化工股份有限公司 2018-11-02 CN disclosed
CN-106146703-B Cationic polymerization method 中国石油化工股份有限公司 2018-10-16 CN disclosed
CN-106146698-B Preparation method of halogenated polymer 中国石油化工股份有限公司 2018-10-16 CN disclosed
CN-106146696-B Cationic polymerization method 中国石油化工股份有限公司 2018-10-16 CN disclosed
CN-106146706-B Cationic polymerization method 中国石油化工股份有限公司 2018-09-21 CN disclosed
CN-106146701-B Preparation method of halogenated polymer 中国石油化工股份有限公司 2018-09-21 CN disclosed
CN-106146707-B Preparation method of halogenated polymer 中国石油化工股份有限公司 2018-09-21 CN disclosed
CN-106146697-B Cationic polymerization method 中国石油化工股份有限公司 2018-09-21 CN disclosed
CN-104558344-A Cationic polymerization initiator system, application thereof and cationic polymerization method CHINA PETROLEUM & CHEMICAL 2015-04-29 CN disclosed
US-20120071523-A1 BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2012-03-22 US disclosed
US-20120071523-A1 BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2012-03-22 US disclosed
CN-101370853-B Electrostatic coatings and articles comprising polythiophenes PLEXTRONICS INC 2011-11-16 CN disclosed
WO-2010129049-A1 BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2010-11-11 WO disclosed
CN-101370853-A Electrostatic coatings and articles comprising polythiophenes PLEXTRONICS INC (US) 2009-02-18 CN disclosed
EP-0990952-B1 Electrophotographic Photoreceptor KONICA CORP (JP) 2007-10-31 EP disclosed
US-6406825-B1 MULTILAYER; SUPPORT, PHOTOSENSITIVE LAYER AND THREE-DIMENSIONAL CROSSLINKED POLYMER KONICA CORPORATION (JP) 2002-06-18 US disclosed
US-6143452-A THREE-DIMENSIONALLY CROSSLINKED SILICONE MODIFIED BY CONDENSATION REACTION OF HYDROLYZABLE GROUPS WITH HYDROXY, AMINO OR MERCAPTO GROUP-FUNCTIONALIZED CHARGE TRANSPORT COMPOUND; WEAR RESISTANCE KONICA CORPORATION 2000-11-07 US disclosed
EP-0990952-A2 Electrophotographic Photoreceptor KONICA CORPORATION (JP) 2000-04-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120071523-A1 BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS PDF, EIF5B, EIF4E S100A4 3047/4885HSP90AA1 152/4885ALDH1A1 3464/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.