SCHEMBL8018138

SCHEMBL8018138

CN(C)CCNS(=O)(=O)Cl

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.60
TSHR P16473 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
PRMT3 O60678 1/20 0.42
CARM1 Q86X55 1/20 0.42
PRMT6 Q96LA8 1/20 0.42
PRMT1 Q99873 1/20 0.42
PRMT8 Q9NR22 1/20 0.42
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
RECQL P46063 1/20 0.40
CA2 P00918 3/20 0.35
CA12 O43570 2/20 0.35
CA9 Q16790 2/20 0.35
KMT2A Q03164 1/20 0.35
GAA P10253 2/20 0.35
ALOX15 P16050 1/20 0.34
PDK1 Q15118 1/20 0.34
PDK2 Q15119 1/20 0.34
PDK3 Q15120 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4398411 0.84 ALDH1A1 (0.43) ALDH1A1TSHRNPSR1CA2CA12
SCHEMBL48345 0.77 ALDH1A1 (0.62) ALDH1A1TSHRNPSR1PRMT3CARM1
SCHEMBL13849296 0.76 ALDH1A1 (0.56) ALDH1A1TSHRNPSR1PRMT3CARM1
SCHEMBL16438219 0.75 ALDH1A1 (0.60) ALDH1A1TSHRNPSR1PRMT3CARM1
SCHEMBL8981500 0.75 ALDH1A1 (0.60) ALDH1A1TSHRNPSR1PRMT3CARM1
SCHEMBL11033708 0.75 ALDH1A1 (1.00) ALDH1A1TSHRNPSR1PRMT3CARM1
SCHEMBL3151454 0.75 ALDH1A1 (0.60) ALDH1A1TSHRNPSR1PRMT3CARM1
SCHEMBL24187300 0.75 ALDH1A1 (0.54) ALDH1A1TSHRNPSR1PRMT3CARM1
SCHEMBL1487362 0.73 ALDH1A1 (0.58) ALDH1A1TSHRNPSR1PRMT3CARM1
SCHEMBL27183099 0.73 ALDH1A1 (0.58) ALDH1A1TSHRNPSR1PRMT3CARM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4323066-A1 MEK INHIBITORS AND USES THEREOF Ikena Oncology, Inc. (US) 2024-02-21 EP disclosed
WO-2022221866-A1 MEK INHIBITORS AND USES THEREOF Ikena Oncology, Inc. (US) 2022-10-20 WO disclosed
EP-0685234-B1 DRUG COMPOSITION CONTAINING NUCLEIC ACID COPOLYMER NIPPON SHINYAKU CO LTD (JP) 2000-05-10 EP disclosed
US-6020317-A Glycerol derivative, device and pharmaceutical composition NIPPON SHINYAKU CO. LTD. (JP) 2000-02-01 US disclosed
EP-0685457-B1 GLYCEROL DERIVATIVE, DEVICE AND PHARMACEUTICAL COMPOSITION NIPPON SHINYAKU CO LTD (JP) 1999-12-15 EP disclosed
US-5705188-A LIPID MIXTURE, ANTITUMOR AGENTS NIPPON SHINYAKU COMPANY, LTD. (JP) 1998-01-06 US disclosed
EP-0685457-A1 GLYCEROL DERIVATIVE, DEVICE AND PHARMACEUTICAL COMPOSITION NIPPON SHINYAKU COMPANY, LIMITED (JP) 1995-12-06 EP disclosed
EP-0685234-A1 DRUG COMPOSITION CONTAINING NUCLEIC ACID COPOLYMER NIPPON SHINYAKU COMPANY, LIMITED (JP) 1995-12-06 EP disclosed