SCHEMBL8018876

SCHEMBL8018876

CNC1CCN(C(=O)CCN(C(Cc2ccc(Cl)cc2)C(=O)NO)S(=O)(=O)c2ccc(OC)cc2)CC1

nearest known ligand 0.51

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
BMP1 P13497 18/20 0.51
MMP1 P03956 2/20 0.51
MMP8 P22894 2/20 0.51
ALDH1A1 P00352 1/20 0.45
GAA P10253 1/20 0.45
KMT2A Q03164 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8012371 0.91 BMP1 (0.51) BMP1MMP1MMP8
Hydrochloric Acid SCHEMBL8003635 0.91 BMP1 (0.57) BMP1MMP1MMP8
Hydrochloric Acid SCHEMBL8019980 0.85 BMP1 (0.50) BMP1MMP1MMP8
Hydrochloric Acid SCHEMBL8015082 0.84 BMP1 (0.49) BMP1MMP1MMP8
SCHEMBL8012119 0.84 MMP1 (0.53) BMP1MMP1MMP8
Hydrochloric Acid SCHEMBL8012988 0.83 BMP1 (0.59) BMP1MMP1MMP8
Hydrochloric Acid SCHEMBL8003579 0.83 MMP1 (0.53) BMP1MMP1MMP8
SCHEMBL8012716 0.83 BMP1 (0.58) BMP1MMP1MMP8
Hydrochloric Acid SCHEMBL8015360 0.83 MMP2 (0.56) BMP1MMP1MMP8
SCHEMBL8012383 0.82 BMP1 (0.53) BMP1MMP1MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6153609-A Arylsulfonylamino hydroxamic acid derivatives PFIZER INC (US) 2000-11-28 US claimed
CN-1228083-A Arylsulfonylamino hydroxamic acid derivatives PFIZER (US) 1999-09-08 CN claimed
EP-0922030-A1 ARYLSULFONYLAMINO HYDROXAMIC ACID DERIVATIVES PFIZER INC. (US) 1999-06-16 EP claimed
WO-1998007697-A1 ARYLSULFONYLAMINO HYDROXAMIC ACID DERIVATIVES PFIZER INC. (US) 1998-02-26 WO claimed
US-6153609-A Arylsulfonylamino hydroxamic acid derivatives PFIZER INC (US) 2000-11-28 US disclosed
CN-1228083-A Arylsulfonylamino hydroxamic acid derivatives PFIZER (US) 1999-09-08 CN disclosed
EP-0922030-A1 ARYLSULFONYLAMINO HYDROXAMIC ACID DERIVATIVES PFIZER INC. (US) 1999-06-16 EP disclosed
WO-1998007697-A1 ARYLSULFONYLAMINO HYDROXAMIC ACID DERIVATIVES PFIZER INC. (US) 1998-02-26 WO disclosed