Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8018983 | 0.87 | L3MBTL1 (0.39) | MEN1KMT2ACTSSCTSKALDH1A1 | |
| SCHEMBL8025163 | 0.87 | SIRT2 (0.40) | SMN1; SMN2MEN1KMT2AALDH1A1CYP2C19 | |
| SCHEMBL8022535 | 0.81 | CYP2C19 (0.52) | SMN1; SMN2MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL8025263 | 0.81 | DPP8 (0.37) | MEN1KMT2ARAB9AMAPT | |
| SCHEMBL8025124 | 0.73 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL8020026 | 0.72 | BACE1 (0.38) | SMN1; SMN2MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL27805616 | 0.72 | KDM1A (0.38) | SMN1; SMN2CTSBCTSSCTSKBCL2 | |
| SCHEMBL2075585 | 0.72 | MAPK1 (0.46) | SMN1; SMN2MEN1KMT2ACTSSCTSK | |
| SCHEMBL27512707 | 0.70 | BACE1 (0.37) | SMN1; SMN2MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL15767766 | 0.70 | KDM1A (0.46) | SMN1; SMN2CTSBCTSSCTSKBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973720-A1 | 2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998040344-A1 | 2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-09-17 | — | — | WO | disclosed |