Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.36 |
| ▸ | CHRNG | P07510 | 1/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8018813 | 0.84 | NPSR1 (0.42) | SMN1; SMN2MEN1KMT2APARP1ALDH1A1 | |
| SCHEMBL8017815 | 0.76 | PARP1 (0.47) | SMN1; SMN2MEN1KMT2APARP1ALDH1A1 | |
| SCHEMBL8018891 | 0.73 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1KMT2APARP1ALDH1A1 | |
| SCHEMBL8022535 | 0.71 | CYP2C19 (0.52) | SMN1; SMN2MEN1KMT2APARP1ALDH1A1 | |
| SCHEMBL27536880 | 0.69 | PARP1 (0.43) | SMN1; SMN2MEN1KMT2APARP1ALDH1A1 | |
| SCHEMBL26145004 | 0.68 | HSD11B1 (0.48) | MEN1KMT2APARP1ALDH1A1TP53 | |
| SCHEMBL30213440 | 0.68 | HSD11B1 (0.48) | MEN1KMT2APARP1ALDH1A1TP53 | |
| SCHEMBL1639877 | 0.68 | HSD11B1 (0.57) | MEN1KMT2APARP1ALDH1A1TP53 | |
| SCHEMBL3169 | 0.67 | PARP1 (0.63) | SMN1; SMN2MEN1KMT2APARP1ALDH1A1 | |
| SCHEMBL30277354 | 0.67 | PARP1 (0.63) | SMN1; SMN2MEN1KMT2APARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973720-A1 | 2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998040344-A1 | 2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-09-17 | — | — | WO | disclosed |