Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 14/20 | 0.59 |
| ▸ | MMP2 | P08253 | 10/20 | 0.59 |
| ▸ | MMP3 | P08254 | 8/20 | 0.59 |
| ▸ | MMP8 | P22894 | 6/20 | 0.58 |
| ▸ | FCER2 | P06734 | 6/20 | 0.58 |
| ▸ | MMP9 | P14780 | 5/20 | 0.58 |
| ▸ | MMP7 | P09237 | 4/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.51 |
| ▸ | MMP12 | P39900 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | MMP14 | P50281 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400674 | 0.85 | PSMB5 (0.69) | MMP1MMP2MMP3MMP8FCER2 | |
| SCHEMBL9068710 | 0.85 | MME (0.55) | MMP2MMP9MMP7MMP12MMP13 | |
| SCHEMBL8006105 | 0.84 | MMP1 (0.51) | MMP1MMP2MMP3MMP8FCER2 | |
| SCHEMBL6413659 | 0.84 | MMP1 (0.61) | MMP1MMP2MMP3MMP8FCER2 | |
| SCHEMBL7403731 | 0.84 | MMP1 (0.61) | MMP1MMP2MMP3MMP8FCER2 | |
| SCHEMBL6421408 | 0.84 | MMP1 (0.56) | MMP1MMP2MMP3MMP8FCER2 | |
| SCHEMBL6416478 | 0.84 | MMP1 (0.64) | MMP1MMP2MMP3MMP8FCER2 | |
| SCHEMBL6415232 | 0.83 | MMP1 (0.60) | MMP1MMP2MMP3MMP8FCER2 | |
| SCHEMBL8510052 | 0.83 | PSMB5 (0.70) | MMP1MMP2MMP3MMP8FCER2 | |
| SCHEMBL9068920 | 0.82 | LTA4H (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728144-B1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | DARWIN DISCOVERY LTD (GB) | 2000-01-19 | — | — | EP | disclosed |
| EP-0728144-A1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | Chiroscience Limited (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013289-A1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | CHIROSCIENCE LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |