Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8032586 | 0.85 | HDAC6 (0.60) | GAAHDAC3HDAC1MAPTHDAC6 | |
| SCHEMBL8029037 | 0.85 | GAA (0.62) | GAAHDAC3HDAC1MAPTHDAC6 | |
| SCHEMBL8030789 | 0.84 | NPC1 (0.65) | GAAHDAC3HDAC1MAPTHDAC6 | |
| SCHEMBL8029023 | 0.78 | HDAC3 (0.60) | GAAHDAC3HDAC1NAMPTHDAC6 | |
| SCHEMBL27291920 | 0.76 | CA2 (0.74) | HDAC3HDAC1MAPTNAMPTCA2 | |
| SCHEMBL8029053 | 0.76 | HDAC6 (0.63) | HDAC3HDAC1MAPTNAMPTHDAC6 | |
| SCHEMBL9913956 | 0.74 | HPGD (0.68) | MAPTNAMPTCA2SMN1; SMN2MEN1 | |
| SCHEMBL8034875 | 0.74 | ALDH1A1 (0.61) | GAAHDAC3HDAC1SMN1; SMN2MEN1 | |
| SCHEMBL9120155 | 0.74 | NAMPT (0.60) | HDAC3HDAC1NAMPTCA2ALDH1A1 | |
| SCHEMBL8030824 | 0.73 | HDAC6 (0.66) | HDAC3HDAC1HDAC6SMN1; SMN2HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0797579-B1 | ERYTHROMYCIN A 9-0-OXIME DERIVATIVES ENDOWED WITH ANTIBIOTIC ACTIVITY | ZAMBON SPA (IT) | 2000-03-15 | — | — | EP | disclosed |
| US-5847092-A | Erythromycin A 9-0 oxime derivatives endowed with antibiotic activity | ZAMBON GROUP S.P.A. (IT) | 1998-12-08 | — | — | US | disclosed |