Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.75 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.73 |
| ▸ | TP53 | P04637 | 2/20 | 0.71 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019490 | 0.91 | HTR6 (0.72) | HTR6RXFP1TP53THRBKDM4E | |
| SCHEMBL8027148 | 0.89 | RXFP1 (0.65) | HTR6RXFP1TP53THRBMAPT | |
| SCHEMBL8019460 | 0.88 | HTR6 (0.60) | HTR6RXFP1TP53THRBMAPT | |
| SCHEMBL8019549 | 0.86 | HTR6 (1.00) | HTR6RXFP1MAPT | |
| SCHEMBL8019579 | 0.86 | HTR6 (0.76) | HTR6RXFP1TP53MAPT | |
| SCHEMBL8015840 | 0.84 | TP53 (0.67) | HTR6RXFP1TP53THRBSMN1; SMN2 | |
| SCHEMBL8029679 | 0.83 | TP53 (1.00) | HTR6RXFP1TP53THRBMAPT | |
| SCHEMBL8018278 | 0.78 | HPGD (0.60) | HTR6RXFP1TP53THRBMAPT | |
| SCHEMBL8026556 | 0.78 | KDM4E (0.64) | HTR6RXFP1TP53THRBMAPT | |
| SCHEMBL8030787 | 0.77 | RXFP1 (0.57) | HTR6RXFP1TP53THRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009093934-A2 | SUBSTITUTED 3-SULPHONYL-[1,2,3]TRIAZOLO [1,5-A]PYRIMIDINES-ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, MEDICINAL SUBSTANCE, PHARMACEUTICAL COMPOSITION, MEDICINAL PREPARATION AND METHODS FOR THE PRODUCTION THEREOF | ALLA CHEM, LLC (US) | 2009-07-30 | — | — | WO | disclosed |