Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | HTR6 | P50406 | 11/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019490 | 0.93 | HTR6 (0.72) | TP53HTR6RXFP1THRBKDM4E | |
| SCHEMBL8027148 | 0.90 | RXFP1 (0.65) | TP53HTR6RXFP1THRBKDM4E | |
| SCHEMBL8018281 | 0.87 | HPGD (0.53) | TP53HTR6RXFP1THRBKDM4E | |
| SCHEMBL8030780 | 0.85 | HTR6 (0.65) | TP53HTR6RXFP1THRBPOLB | |
| SCHEMBL8019551 | 0.84 | HTR6 (0.75) | TP53HTR6RXFP1THRBKDM4E | |
| SCHEMBL8018278 | 0.80 | HPGD (0.60) | TP53HTR6RXFP1THRBKDM4E | |
| SCHEMBL8029679 | 0.80 | TP53 (1.00) | TP53HTR6RXFP1THRBSMN1; SMN2 | |
| SCHEMBL8028973 | 0.78 | HTR6 (0.73) | TP53HTR6RXFP1THRB | |
| SCHEMBL8029076 | 0.78 | HTR6 (1.00) | TP53HTR6RXFP1 | |
| SCHEMBL8029045 | 0.77 | KDM4E (0.61) | TP53HTR6RXFP1THRBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009093934-A2 | SUBSTITUTED 3-SULPHONYL-[1,2,3]TRIAZOLO [1,5-A]PYRIMIDINES-ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, MEDICINAL SUBSTANCE, PHARMACEUTICAL COMPOSITION, MEDICINAL PREPARATION AND METHODS FOR THE PRODUCTION THEREOF | ALLA CHEM, LLC (US) | 2009-07-30 | — | — | WO | disclosed |