Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 13/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 9/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 8/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8007390 | 1.00 | OPRK1 (1.00) | OPRK1OPRM1OPRD1MEN1KMT2A | |
| SCHEMBL8017684 | 1.00 | OPRK1 (1.00) | OPRK1OPRM1OPRD1MEN1KMT2A | |
| SCHEMBL8018359 | 0.93 | OPRK1 (0.87) | OPRK1OPRM1OPRD1 | |
| SCHEMBL8017641 | 0.93 | OPRK1 (0.87) | OPRK1OPRM1OPRD1 | |
| SCHEMBL8017637 | 0.93 | OPRK1 (0.87) | OPRK1OPRM1OPRD1 | |
| SCHEMBL8018088 | 0.88 | OPRM1 (0.79) | OPRK1OPRM1OPRD1MEN1KMT2A | |
| SCHEMBL8018166 | 0.88 | OPRM1 (0.79) | OPRK1OPRM1OPRD1MEN1KMT2A | |
| SCHEMBL8018087 | 0.88 | OPRM1 (0.79) | OPRK1OPRM1OPRD1MEN1KMT2A | |
| SCHEMBL10421575 | 0.88 | OPRK1 (0.78) | OPRK1OPRM1OPRD1MEN1KMT2A | |
| SCHEMBL10421573 | 0.88 | OPRK1 (0.78) | OPRK1OPRM1OPRD1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114381-A | TO CONTROL BRAIN DAMAGE ASSOCIATED WITH ANOXIA OR ISCHEMIA WHICH TYPICALLY FOLLOWS STROKE, CARDIAC ARREST OR PERINATAL ASPHYXIA; COMPOUND IS AN ANTAGONIST TO INHIBIT EXCITOTOXIC ACTIONS AT EXCITATORY AMINO ACID RECEPTOR SITES | G. D. SEARLE & CO. (US) | 2000-09-05 | — | — | US | disclosed |