Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.57 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029855 | 0.84 | SIGMAR1 (0.76) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL15707823 | 0.80 | HRH3 (0.67) | SIGMAR1HRH3ABCB1HRH4DRD2 | |
| SCHEMBL8029610 | 0.78 | AIMP2 (0.53) | SIGMAR1 | |
| SCHEMBL15707813 | 0.78 | HRH3 (0.51) | SIGMAR1HRH3ABCB1HRH4DRD2 | |
| SCHEMBL15740462 | 0.77 | HRH3 (0.50) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL20274162 | 0.76 | HRH3 (0.49) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL15750188 | 0.76 | HRH3 (0.49) | HRH3ABCB1HRH4DRD2 | |
| SCHEMBL8031447 | 0.76 | SIGMAR1 (0.81) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL31061719 | 0.74 | SIGMAR1 (1.00) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8031431 | 0.74 | SIGMAR1 (1.00) | SIGMAR1HTR1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702010-B1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-15 | — | — | EP | claimed |
| EP-0702010-A1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-03-20 | — | — | EP | claimed |
| JP-8081451-A | — | — | None | — | — | JP | disclosed |
| EP-0702010-B1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-15 | — | — | EP | disclosed |
| US-5691340-A | CENTRAL NERVOUS SYSTEM DISORDERS, STROKES, CARDIOVASCULAR DISORDERS, ALZHEIMER*S DISEASE OR ANTIINFLAMMATORY AGENTS | ADIR ET COMPAGNIE (FR) | 1997-11-25 | — | — | US | disclosed |
| US-5668138-A | AFFINITY FOR SIGMA RECEPTORS, CENTRAL NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-09-16 | — | — | US | disclosed |
| JP-H0881451-A | NOVEL BENZOPYRAN DERIVATIVE, ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | ADIR | 1996-03-26 | — | — | JP | disclosed |
| EP-0702010-A1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-03-20 | — | — | EP | disclosed |