Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8022535 | 0.85 | CYP2C19 (0.52) | MAPK1CYP2C19NPC1RAB9AMEN1 | |
| SCHEMBL8018575 | 0.85 | MAPK1 (0.52) | MAPK1CYP2C19KCNK3KCNK9NPC1 | |
| SCHEMBL8008318 | 0.74 | GRM2 (0.52) | KCNK3KCNK9NPC1RAB9AGRM5 | |
| SCHEMBL8018813 | 0.71 | NPSR1 (0.42) | CYP2C19KCNK3KCNK9NPC1RAB9A | |
| SCHEMBL7417055 | 0.69 | MAPK1 (1.00) | MAPK1CYP2C19MEN1KMT2AP2RX7 | |
| SCHEMBL1740252 | 0.67 | MAPK1 (0.60) | MAPK1CYP2C19KCNK3KCNK9MEN1 | |
| SCHEMBL24118572 | 0.67 | KCNK3 (0.50) | KCNK3KCNK9NPC1RAB9AGRM5 | |
| SCHEMBL1578574 | 0.67 | FAAH (0.60) | NPC1RAB9AGRM5MEN1KMT2A | |
| SCHEMBL3794687 | 0.67 | NPC1 (1.00) | KCNK3KCNK9NPC1RAB9AMEN1 | |
| SCHEMBL13753617 | 0.66 | TP53 (0.56) | KCNK3KCNK9NPC1RAB9AGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973720-A1 | 2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998040344-A1 | 2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-09-17 | — | — | WO | disclosed |