Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 13/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.46 |
| ▸ | PLK4 | O00444 | 3/20 | 0.44 |
| ▸ | PAK4 | O96013 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12619893 | 0.87 | CYP1A2 (0.51) | CYP1A2JAK2AURKAAURKBRIPK1 | |
| SCHEMBL802687 | 0.80 | PAK4 (0.43) | CYP1A2JAK2AURKAAURKBPLK4 | |
| SCHEMBL802734 | 0.78 | AURKA (0.50) | AURKAAURKBRIPK1NTRK1 | |
| SCHEMBL802067 | 0.74 | AURKA (0.38) | CYP1A2AURKAAURKBPLK4PAK4 | |
| SCHEMBL13055206 | 0.74 | AURKA (0.40) | JAK2AURKAAURKBRIPK1NTRK1 | |
| Hydrochloric Acid SCHEMBL28463160 | 0.72 | AURKA (0.55) | JAK2AURKAAURKBRIPK1NTRK1 | |
| SCHEMBL3793220 | 0.72 | AURKA (0.64) | JAK2AURKAAURKBNTRK1PLK4 | |
| SCHEMBL1704417 | 0.71 | KARS1 (0.76) | JAK2AURKAAURKBRIPK1ITK | |
| SCHEMBL802717 | 0.71 | CYP1A2 (0.50) | CYP1A2AURKASRCCHEK1CLK4 | |
| SCHEMBL18790992 | 0.70 | CYP1A2 (0.60) | CYP1A2CLK4ADRB1NCF1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633210-B2 | Triazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-01-21 | — | — | US | disclosed |
| US-20120071657-A1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-22 | — | — | US | disclosed |
| US-20120071657-A1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071657-A1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | GSK3B, GSK3A, CDK19 | CYP1A2 3042/4885JAK2 248/4885AURKA 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.