Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 15/20 | 0.76 |
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901824 | 0.86 | KARS1 (1.00) | KARS1 | |
| SCHEMBL1705645 | 0.85 | KARS1 (0.56) | KARS1ITKJAK2AURKAAURKB | |
| SCHEMBL1704207 | 0.84 | KARS1 (0.66) | KARS1ITKJAK2AURKAAURKB | |
| SCHEMBL902162 | 0.83 | KARS1 (1.00) | KARS1 | |
| SCHEMBL902600 | 0.82 | KARS1 (1.00) | KARS1 | |
| SCHEMBL1704227 | 0.81 | KARS1 (0.73) | KARS1 | |
| SCHEMBL1704773 | 0.81 | KARS1 (0.51) | KARS1 | |
| SCHEMBL901740 | 0.80 | KARS1 (1.00) | KARS1 | |
| SCHEMBL1704457 | 0.78 | ITK (0.55) | KARS1ITKAURKAAURKB | |
| SCHEMBL902289 | 0.76 | ITK (0.54) | KARS1ITKAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |