Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.54 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 4/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | PELI1 | Q96FA3 | 2/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15846309 | 0.97 | ZDHHC20 (0.58) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Trimethylammonium SCHEMBL3681199 | 0.92 | ZDHHC20 (0.53) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Trimethylammonium SCHEMBL5961784 | 0.92 | ZDHHC20 (0.53) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Sulfuric Acid SCHEMBL7864545 | 0.86 | ZDHHC20 (0.66) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| SCHEMBL15846409 | 0.83 | ZDHHC20 (0.54) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Ethylamine SCHEMBL6158519 | 0.83 | ZDHHC20 (0.50) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Trimethylammonium SCHEMBL27979802 | 0.83 | ZDHHC20 (0.63) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Trimethylammonium SCHEMBL1232298 | 0.83 | ZDHHC20 (0.63) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| SCHEMBL15846955 | 0.82 | ZDHHC20 (0.47) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Sulfuric Acid SCHEMBL9324961 | 0.82 | ZDHHC20 (0.61) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972110-A1 | METHOD FOR PRODUCING HIGH DRY-STRENGTH PAPER, PULPBOARD AND CARDBOARD | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045536-A1 | METHOD FOR PRODUCING HIGH DRY-STRENGTH PAPER, PULPBOARD AND CARDBOARD | BASF AKTIENGESELLSCHAFT (DE) | 1998-10-15 | — | — | WO | disclosed |