Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | THRA | P10827 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 8/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.41 |
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MPC2 | O95563 | 1/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10639426 | 0.93 | MEN1 (0.43) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| SCHEMBL10969847 | 0.87 | CYP3A4 (0.43) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| SCHEMBL10640256 | 0.85 | MEN1 (0.49) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| SCHEMBL10639191 | 0.85 | MEN1 (0.52) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| SCHEMBL10639005 | 0.83 | MEN1 (0.54) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| SCHEMBL10636378 | 0.82 | MEN1 (0.40) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| SCHEMBL7455277 | 0.81 | ALDH1A1 (0.56) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| SCHEMBL10639049 | 0.79 | CYP3A4 (0.56) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| SCHEMBL10640431 | 0.79 | MEN1 (0.41) | MEN1MAPTKMT2ATDP1ALDH1A1 | |
| SCHEMBL10641884 | 0.79 | MEN1 (0.50) | MEN1MAPTKMT2ATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110951-A | LOWERING INSULIN DRUG THERAPY IN NON-OBESE, NON-DIABETIC INDIVIDUALS | BETHESDA PHARMACEUTICALS, INC. | 2000-08-29 | — | — | US | disclosed |
| US-5594015-A | Thiazolidine derivatives for the treatment of psoriasis | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-01-14 | — | — | US | disclosed |
| US-5053420-A | Antidiabetic agents | KURTZ, THEODORE W. | 1991-10-01 | — | — | US | disclosed |
| WO-1991005538-A2 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | PERSHADSINGH HARRIHAR A (US) | 1991-05-02 | — | — | WO | disclosed |
| EP-0139421-B1 | THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SANKYO COMPANY LIMITED (JP) | 1988-04-27 | — | — | EP | disclosed |
| US-4572912-A | Thiazolidine derivatives, their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1986-02-25 | — | — | US | disclosed |
| EP-0139421-A1 | Thiazolidine derivatives, their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1985-05-02 | — | — | EP | disclosed |