Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8586269 | 0.91 | MTNR1A (0.61) | MTNR1AMTNR1BHTR2AHTR1DHTR6 | |
| SCHEMBL17785108 | 0.82 | MTNR1A (0.65) | MTNR1AMTNR1BMAPTCYP2A6MEN1 | |
| SCHEMBL19611336 | 0.82 | MTNR1A (0.61) | MTNR1AMTNR1BHTR2AHTR1DHTR6 | |
| SCHEMBL8030991 | 0.80 | CA2 (0.54) | MTNR1AMTNR1BHTR2AHTR1DMAPT | |
| SCHEMBL25030227 | 0.79 | MTNR1A (0.70) | MTNR1AMTNR1BHTR2AHTR6 | |
| SCHEMBL25029849 | 0.79 | MTNR1A (0.59) | MTNR1AMTNR1BHTR2AHTR1DHTR6 | |
| SCHEMBL8587828 | 0.79 | TAAR1 (0.53) | MTNR1AMTNR1BHTR2AHTR1DHTR6 | |
| SCHEMBL8617176 | 0.79 | MTNR1A (0.54) | MTNR1AMTNR1BMAPTCYP2A6BACE1 | |
| SCHEMBL6151456 | 0.78 | MTNR1A (0.60) | MTNR1AMTNR1BMAPTCYP2A6MEN1 | |
| SCHEMBL7340610 | 0.78 | MTNR1A (0.57) | MTNR1AMTNR1BMAPTTSHRCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745586-B1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-08 | — | — | EP | disclosed |
| US-5760071-A | AN UREA OR THIOUREA COMPOUNDS FOR TREATING MELATONINERGIC SYSTEM DISORDER, SLEEP DISORDER | ADIR ET COMPAGNIE (FR) | 1998-06-02 | — | — | US | disclosed |
| US-5731352-A | THERAPY FOR DISORDERS OF THE MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-03-24 | — | — | US | disclosed |
| EP-0745586-A1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |